Jaffe N, Smith D, Jaffe M R, Hudson M, Carrasco H, Wallace S, Raymond A K, Ayala A, Murray J, Robertson R
Division of Pediatrics, University of Texas M.D. Anderson Caner Center, Houston 77030.
Clin Orthop Relat Res. 1991 Sep(270):15-21.
Sixty patients with extremity osteosarcoma were treated with intraarterial cisplatin. This was followed by surgical resection (amputation or limb salvage) and postoperative adjuvant chemotherapy utilizing two different protocols. Seventy-five percent of patients achieved an initial response. Overall disease-free survival was 58%. The number of patients treated with limb-salvage surgery gradually increased to the extent that 80% of newly-registered patients achieved a response and were subjected to limb salvage. Disease-free survival was 48% in amputation and 68% in limb salvage. The only factors found to have prognostic significance in determining disease-free survival were extent of tumor destruction induced by preoperative chemotherapy and tumor size.
60例肢体骨肉瘤患者接受了动脉内顺铂治疗。随后进行手术切除（截肢或保肢），并采用两种不同方案进行术后辅助化疗。75%的患者获得了初始缓解。总体无病生存率为58%。接受保肢手术治疗的患者数量逐渐增加，以至于80%的新登记患者获得缓解并接受了保肢治疗。截肢患者的无病生存率为48%，保肢患者为68%。在确定无病生存率方面，唯一被发现具有预后意义的因素是术前化疗引起的肿瘤破坏程度和肿瘤大小。
