加兰他敏用于治疗可能患有或未患有脑血管疾病的泰国阿尔茨海默病患者的行为和心理症状。
Galantamine for the treatment of BPSD in Thai patients with possible Alzheimer's disease with or without cerebrovascular disease.
作者信息
Tangwongchai S, Thavichachart N, Senanarong V, Poungvarin N, Phanthumchinda K, Praditsuwan R, Nidhinandana S, Chankrachang S
机构信息
Department of Psychiatry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Am J Alzheimers Dis Other Demen. 2008;23(6):593-601. doi: 10.1177/1533317508320603. Epub 2008 Oct 9.
OBJECTIVES
This study was to investigate an efficacy of galantamine in treatment of behavioral and psychological symptoms of dementia in Thai elderly who suffered from possible Alzheimer's disease (AD) with or without cerebrovascular disease and vascular dementia.
METHODS
A 6-month, multicenter, open-label, uncontrolled trial was undertaken in 75 patients. Eligible patients received an initial galantamine dose of 8 mg/dayand escalated over 5 to 8 weeks to maintenance doses of 16 or 24 mg/day. The behavioral response was assessed as an intention-to-treat analysis using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD).
RESULTS
Galantamine improved behavioral and psychological symptoms of dementia (P < .05 vs baseline) over the 24 weeks of treatment. BEHAVE-AD score was significantly improved from baseline in paranoid and delusion ideation, diurnal rhythm disturbances, anxieties, and phobias.
CONCLUSIONS
Galantamine may be a well-tolerated and effective treatment option for improving psychotic, behavioral, and psychological symptoms in Thai elderly with possible AD with or without cerebrovascular disease and vascular dementia.
目的
本研究旨在调查加兰他敏对患有可能的阿尔茨海默病（AD）且伴有或不伴有脑血管疾病及血管性痴呆的泰国老年痴呆患者行为和心理症状的治疗效果。
方法
对75例患者进行了一项为期6个月的多中心、开放标签、非对照试验。符合条件的患者初始加兰他敏剂量为8毫克/天，并在5至8周内逐渐增加至16或24毫克/天的维持剂量。使用阿尔茨海默病行为病理评定量表（BEHAVE-AD）对行为反应进行意向性分析评估。
结果
在24周的治疗期间，加兰他敏改善了痴呆的行为和心理症状（与基线相比，P < 0.05）。BEHAVE-AD评分在偏执和妄想观念、昼夜节律紊乱、焦虑和恐惧症方面较基线有显著改善。
结论
对于患有可能的AD且伴有或不伴有脑血管疾病及血管性痴呆的泰国老年患者，加兰他敏可能是一种耐受性良好且有效的治疗选择，可改善其精神病性、行为和心理症状。
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