七价肺炎球菌结合疫苗引入后西班牙肺炎球菌性脑膜炎发病率下降

Decline in pneumococcal meningitis in Spain after introduction of the heptavalent pneumococcal conjugate vaccine.

作者信息

Casado-Flores Juan, Rodrigo Carlos, Arístegui Javier, Martínón Jose María, Fenoll Asunción, Mendez Cristina

机构信息

Hospital Niño Jesús, Madrid, Spain.

出版信息

Pediatr Infect Dis J. 2008 Nov;27(11):1020-2. doi: 10.1097/INF.0b013e31817bd2dc.

DOI:10.1097/INF.0b013e31817bd2dc

PMID:18845983

Abstract

All patients < or =14 years old with a diagnosis of pneumococcal meningitis (n = 160) were included (2001, 2004-2006). Incidence per 100,000 child <5 years old varied from 6.14 in 2001 to 2.83 in 2006 (54% of reduction, P < 0.01). There was a significant correlation (R2 = 0.9506) with PCV7 distribution increase. No significant changes in the incidence by nonvaccine serotypes were found when comparing 2001 and 2006. The case fatality rate was 7.5%.

摘要

纳入了所有2001年、2004 - 2006年诊断为肺炎球菌性脑膜炎且年龄小于或等于14岁的患者（n = 160）。每10万名5岁以下儿童的发病率从2001年的6.14降至2006年的2.83（降低了54%，P < 0.01）。这与PCV7疫苗接种率的上升存在显著相关性（R2 = 0.9506）。比较2001年和2006年时，未发现非疫苗血清型的发病率有显著变化。病死率为7.5%。