Kuang Sheng-Li, Hu Bing, Jiang Li-Xin, He Pei-Zhong, Xia Rong-Min, Shou Wen-De
Department of Ultrasound in Medicine, Shanghai Jiaotong University affiliated Sixth People's Hospital, Shanghai, China.
Minim Invasive Ther Allied Technol. 2008;17(5):285-91. doi: 10.1080/13645700802274281.
The volume of the lesions created by conventional single-frequency high-intensity focused ultrasound (HIFU) is small, which leads to long treatment duration in patients who are undergoing tumor ablation. In this study, the lesions induced by confocal dual-frequency HIFU in an optically transparent tissue-mimicking phantom were investigated and compared with the lesions created by conventional single-frequency HIFU. The results show that using different exposure times resulted in lesions of different sizes in both dual-frequency and single-frequency HIFU modes at the same spatially averaged intensity level (ISAL = 4900 W cm(-2)), but the lesion dimensions made in dual-frequency mode were significantly larger than those made in single-frequency mode. Difference frequency acoustic fields that exist in the confocal region of dual-frequency HIFU may be the reason for the enlargement of the lesions' dimensions. The dual-frequency HIFU mode may represent a new technique to improve the ablation efficiency of HIFU. The total time for the ablation of a tumor can be reduced, thus requiring less therapy time and reducing possible patient complications.
传统单频高强度聚焦超声（HIFU）产生的病灶体积较小，这导致肿瘤消融患者的治疗时间较长。在本研究中，对共焦双频HIFU在光学透明组织模拟体模中诱导产生的病灶进行了研究，并与传统单频HIFU产生的病灶进行了比较。结果表明，在相同的空间平均强度水平（ISAL = 4900 W cm(-2)）下，使用不同的暴露时间在双频和单频HIFU模式下均产生了不同大小的病灶，但双频模式下产生的病灶尺寸明显大于单频模式下的病灶尺寸。双频HIFU共焦区域中存在的差频声场可能是病灶尺寸增大的原因。双频HIFU模式可能代表一种提高HIFU消融效率的新技术。可以减少肿瘤消融的总时间，从而减少治疗时间并降低患者可能出现的并发症。
