Myrmel Truls, Roaldsen Marius
Scand Cardiovasc J. 2009 Feb;43(1):7-9. doi: 10.1080/14017430802403924.
During the last three decades, the most prevalent surgical mitral valve disease in Scandinavia has changed from the sequelae of rheumatic fever to the mitral valve pathologies related to ischemic heart disease. Also, the total number of patients in need of a mitral valve procedure is increasing. For several of the patients with ischemic mitral valve disease, the natural prognosis of their disease is dismal. However, there are several uncertainties as to whether or not a surgical procedure can improve the life expectancies of these patients. Also, the procedures of choice for patients with ischemia related "functional mitral valve disease" is a long standing controversy. In this issue of "Scandinavian Cardiovascular Journal" we present the rationale and protocol for the "MoMIC" trial, a randomized multicenter study aiming to clarify whether revascularization alone or a combined revascularization and mitral valve annuloplasty is the treatment of choice for patients with ischemia related moderate mitral regurgitation.
在过去三十年中,斯堪的纳维亚半岛最常见的外科二尖瓣疾病已从风湿热后遗症转变为与缺血性心脏病相关的二尖瓣病变。此外,需要进行二尖瓣手术的患者总数也在增加。对于一些患有缺血性二尖瓣疾病的患者来说,其自然病程预后不佳。然而,手术是否能改善这些患者的预期寿命仍存在一些不确定性。此外,对于缺血相关的“功能性二尖瓣疾病”患者的首选手术方式,长期以来一直存在争议。在本期《斯堪的纳维亚心血管杂志》中,我们介绍了“MoMIC”试验的基本原理和方案,这是一项随机多中心研究,旨在阐明单纯血运重建或血运重建联合二尖瓣环成形术是否是缺血相关中度二尖瓣反流患者的首选治疗方法。