Emdin Michele, Fontana Marianna, Poletti Roberta, Gabutti Alessandra, Mammini Chiara, Rossi Andrea, Pastormerlo Luigi Emilio, Masi Lorenzo, Passino Claudio, Clerico Aldo
Cardiovascular Medicine Department, G. Monasterio Foundation, CNR Regione Toscana, CNR Institute of Clinical Physiology, Pisa, Italy.
Clin Chem Lab Med. 2008;46(11):1533-42. doi: 10.1515/CCLM.2008.297.
The evaluation of cardiac endocrine function by means of automated robust assays has permitted the introduction of a cheap and powerful clinical tool. Plasma concentration of B-type-related natriuretic peptides is a marker of either hemodynamic or neurohormonal stress on the heart and has been validated within the diagnostic and prognostic domain in patients with suspected or ascertained heart failure, mostly in the in-hospital setting. Evidence is growing, supporting an out-of-hospital use, namely in primary care. Its implementation in this setting in screening programs and diagnostic algorithms might contribute to decrease the apparent disparity between the general practitioner and the specialist approach to disease management.
通过自动化稳健检测方法对心脏内分泌功能进行评估，使得一种廉价且强大的临床工具得以引入。B型利钠肽的血浆浓度是心脏血流动力学或神经激素应激的标志物，并且已在疑似或确诊心力衰竭患者的诊断和预后领域得到验证，主要是在医院环境中。越来越多的证据支持其在院外使用，即在初级保健中使用。在筛查项目和诊断算法中在这种情况下实施它，可能有助于减少全科医生和专科医生在疾病管理方法上明显的差异。
