Bogdanov M B
Farmakol Toksikol. 1991 Mar-Apr;54(2):14-7.
The effect of the electrical nerve stimulation with low (2-4 V, 100 Hz, 5 min) and high (45 V, 1 Hz, 1 min) intensity on the nociceptive responses in the ventrolateral tracts was studied in unanesthetized rats with the transsected spinal cord. Both kinds of stimulation reduced nociceptive responses but the effect of low-intensity stimulations was diminished when they were repeated and was absent over 24 hours after spinalization. The effect of low-intensity stimulation was abolished by naloxone (0.1 and 1 mg/kg) and was reduced during the antinociceptive effect of morphine (1 and 4 mg/kg). The effect of high-intensity stimulation was preserved over 24 hours after spinalization and after repeated stimulations. It was not changed by naloxone and morphine.
在脊髓横断的未麻醉大鼠中，研究了低强度（2 - 4 V，100 Hz，5分钟）和高强度（45 V，1 Hz，1分钟）电神经刺激对腹外侧束伤害性反应的影响。两种刺激均能降低伤害性反应，但低强度刺激重复时效果减弱，脊髓横断24小时后则无此效果。低强度刺激的效果可被纳洛酮（0.1和1 mg/kg）消除，且在吗啡（1和4 mg/kg）的抗伤害作用期间减弱。高强度刺激的效果在脊髓横断后及重复刺激24小时后仍得以保留。它不受纳洛酮和吗啡的影响。
