Kovalev O A
Farmakol Toksikol. 1991 Mar-Apr;54(2):23-5.
In chronic experiments on conscious and quiet rats norepinephrine, isoproterenol, ether, hexenal and ketamine narcosis decreased the cerebral fraction of cardiac output but increased transcapillary filtration in tissues of rubidium chloride and blood supply in the capacitive part of blood vessels. The changes produced by pyroxan, obsidan and ornid in the same conditions were insignificant. A decrease of the cerebral fraction of cardiac output, an increase of transcapillary filtration of rubidium in the brain tissues and regional blood supply took place under the action of pyroxan, obsidan and ornid in experiments with immobilization of rats.
在对清醒安静大鼠进行的慢性实验中，去甲肾上腺素、异丙肾上腺素、乙醚、己醛和氯胺酮麻醉降低了心输出量的脑部分配比例，但增加了氯化铷组织中的跨毛细血管滤过以及血管容量部分的血液供应。在相同条件下，吡罗昔康、黑曜石和奥尼德所产生的变化不显著。在大鼠固定的实验中，吡罗昔康、黑曜石和奥尼德的作用下，心输出量的脑部分配比例降低，脑组织中铷的跨毛细血管滤过及局部血液供应增加。
