van Hoek Ingrid M, Peremans Kathelijne, Vandermeulen Eva, Duchateau Luc, Gommeren Kris, Daminet Sylvie
Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
J Feline Med Surg. 2009 Apr;11(4):309-14. doi: 10.1016/j.jfms.2008.07.007. Epub 2008 Oct 9.
This study investigated the thyroidal response to administration of recombinant human thyroid stimulating hormone (rhTSH) by means of serum total thyroxine (TT(4)) concentration and pertechnetate uptake by the thyroid gland in six healthy euthyroid spayed female cats. A pertechnetate scan was performed on day 1 to calculate thyroid/salivary gland (T/S) uptake ratio. On day 3, 25 microg rhTSH was injected intravenously. Six hours later the thyroid scan was repeated as on day 1. Blood was drawn for serum TT(4) measurement prior to injection of rhTSH and performance of the pertechnetate scan. Statistically significant differences in mean serum TT(4) concentration, T/S uptake ratio before and 6h after rhTSH administration and T/S uptake ratio between left and right lobes were noted. We can conclude that 25 microg rhTSH increases pertechnetate uptake in the thyroid glands of cats, this should be taken into account when thyroid scintigraphy after rhTSH administration is interpreted.
本研究通过测定6只健康甲状腺功能正常的绝育雌性猫的血清总甲状腺素（TT(4)）浓度以及甲状腺对高锝酸盐的摄取情况，研究了重组人促甲状腺激素（rhTSH）给药后的甲状腺反应。在第1天进行高锝酸盐扫描以计算甲状腺/唾液腺（T/S）摄取率。在第3天，静脉注射25微克rhTSH。6小时后，像第1天那样重复进行甲状腺扫描。在注射rhTSH和进行高锝酸盐扫描之前采集血液用于测定血清TT(4)。观察到rhTSH给药前和给药后6小时的平均血清TT(4)浓度、T/S摄取率以及左右叶之间的T/S摄取率存在统计学显著差异。我们可以得出结论，25微克rhTSH可增加猫甲状腺对高锝酸盐的摄取，在解释rhTSH给药后的甲状腺闪烁扫描结果时应考虑到这一点。
