Tonkin M A
Department of Hand Surgery and Peripheral Nerve Surgery, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, 2065 NSW, Australie.
Chir Main. 2008 Dec;27 Suppl 1:S27-34. doi: 10.1016/j.main.2008.08.001. Epub 2008 Aug 27.
Increasing knowledge of the molecular basis of embryonic development has improved our understanding of congenital limb malformations. The most popular current surgical classification of congenital limb anomalies is the Swanson/IFSSH classification. This is based on morphology (appearance). Such a classification is unable to indicate the site in the molecular pathway and/or the anatomical site in the limb bud, nor the time at which the insult occurs. Attempts to alter a classification based on morphology according to increased knowledge of the molecular basis of limb development are flawed. Perhaps it is better to simply describe and document the malformations appearing in any particular limb until such time as a valid classification relating to causation and aetiology at a molecular level can be established.
对胚胎发育分子基础的了解不断增加,增进了我们对先天性肢体畸形的认识。目前最常用的先天性肢体异常外科分类是斯旺森/国际手外科联合会(IFSSH)分类。这一分类基于形态学(外观)。这样的分类无法指出分子途径中的位点和/或肢体芽中的解剖学位点,也无法指出损伤发生的时间。根据对肢体发育分子基础的更多了解来改变基于形态学的分类的尝试存在缺陷。也许最好的办法是简单地描述和记录出现在任何特定肢体上的畸形,直到能够建立一个与分子水平的病因和发病机制相关的有效分类。