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听觉皮层中神经活动的毫秒级差异能够驱动决策。

Millisecond-scale differences in neural activity in auditory cortex can drive decisions.

作者信息

Yang Yang, DeWeese Michael R, Otazu Gonzalo H, Zador Anthony M

机构信息

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

出版信息

Nat Neurosci. 2008 Nov;11(11):1262-3. doi: 10.1038/nn.2211. Epub 2008 Oct 12.

DOI:10.1038/nn.2211
PMID:18849984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4062077/
Abstract

Neurons in the auditory cortex can lock to the fine timing of acoustic stimuli with millisecond precision, but it is not known whether this precise spike timing can be used to guide decisions. We used chronically implanted microelectrode pairs to stimulate neurons in the rat auditory cortex directly and found that rats can exploit differences in the timing of cortical activity that are as short as 3 ms to guide decisions.

摘要

听觉皮层中的神经元能够以毫秒级的精度锁定声音刺激的精确时间,但尚不清楚这种精确的尖峰时间是否可用于指导决策。我们使用长期植入的微电极对直接刺激大鼠听觉皮层中的神经元,发现大鼠能够利用短至3毫秒的皮层活动时间差异来指导决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f306/4062077/90fef01b6d60/nihms559999f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f306/4062077/90fef01b6d60/nihms559999f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f306/4062077/90fef01b6d60/nihms559999f1.jpg

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Nature. 2008 Jan 3;451(7174):61-4. doi: 10.1038/nature06445.
2
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Nature. 2008 Jan 3;451(7174):65-8. doi: 10.1038/nature06447. Epub 2007 Dec 19.
3
Behavioral detection of electrical microstimulation in different cortical visual areas.不同皮层视觉区域电微刺激的行为检测
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4
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Nat Commun. 2024 Jul 17;15(1):6023. doi: 10.1038/s41467-024-49895-6.
5
MnO Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons.MnO 纳米花集成光电生物界面用于神经元的光刺激。
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6
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7
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Nat Commun. 2023 Apr 3;14(1):1858. doi: 10.1038/s41467-023-37613-7.
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Front Integr Neurosci. 2022 Oct 3;16:900715. doi: 10.3389/fnint.2022.900715. eCollection 2022.
9
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4
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