位于20号染色体短臂11区的男性型秃发易感基因座。
Male-pattern baldness susceptibility locus at 20p11.
作者信息
Richards J Brent, Yuan Xin, Geller Frank, Waterworth Dawn, Bataille Veronique, Glass Daniel, Song Kijoung, Waeber Gerard, Vollenweider Peter, Aben Katja K H, Kiemeney Lambertus A, Walters Bragi, Soranzo Nicole, Thorsteinsdottir Unnur, Kong Augustine, Rafnar Thorunn, Deloukas Panos, Sulem Patrick, Stefansson Hreinn, Stefansson Kari, Spector Tim D, Mooser Vincent
机构信息
Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
出版信息
Nat Genet. 2008 Nov;40(11):1282-4. doi: 10.1038/ng.255. Epub 2008 Oct 12.
Abstract
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).
摘要
我们对1125名男性进行了雄激素性脱发的全基因组关联研究，并在20号染色体p11.22区域发现了一个新的关联位点，该位点在三个独立队列中得到验证（n = 1650；rs1160312的比值比为1.60，P = 1.1×10⁻¹⁴）。在20p11.22和AR（编码雄激素受体）位点均携带风险等位基因的男性中，患雄激素性脱发的几率增加了7倍（比值比为7.12，P = 3.7×10⁻¹⁵）。
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