Drum M G, Les C M, Park R D, Norrdin R W, McIlwraith C W, Kawcak C E
Equine Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Bone. 2009 Feb;44(2):316-9. doi: 10.1016/j.bone.2008.08.129. Epub 2008 Sep 19.
The purpose of this study was to compare subchondral bone density obtained using quantitative computed tomography with ash density values from intact equine joints, and to determine if there are measurable anatomic variations in mean subchondral bone density. Five adult equine metacarpophalangeal joints were scanned with computed tomography (CT), disarticulated, and four 1-cm(3) regions of interest (ROI) cut from the distal third metacarpal bone. Bone cubes were ashed, and percent mineralization and ash density were recorded. Three-dimensional models were created of the distal third metacarpal bone from CT images. Four ROIs were measured on the distal aspect of the third metacarpal bone at axial and abaxial sites of the medial and lateral condyles for correlation with ash samples. Overall correlations of mean quantitative CT (QCT) density with ash density (r=0.82) and percent mineralization (r=0.93) were strong. There were significant differences between abaxial and axial ROIs for mean QCT density, percent bone mineralization and ash density (p<0.05). QCT appears to be a good measure of bone density in equine subchondral bone. Additionally, differences existed between axial and abaxial subchondral bone density in the equine distal third metacarpal bone.
本研究的目的是比较使用定量计算机断层扫描获得的软骨下骨密度与完整马关节的灰分密度值，并确定平均软骨下骨密度是否存在可测量的解剖学差异。对五个成年马掌指关节进行计算机断层扫描（CT），然后将关节分离，并从第三掌骨远端切下四个1立方厘米的感兴趣区域（ROI）。将骨块进行灰化处理，并记录矿化百分比和灰分密度。根据CT图像创建第三掌骨远端的三维模型。在第三掌骨远端内侧和外侧髁的轴向和背侧部位测量四个ROI，以与灰分样本进行相关性分析。平均定量CT（QCT）密度与灰分密度（r = 0.82）和矿化百分比（r = 0.93）的总体相关性很强。背侧和轴向ROI在平均QCT密度、骨矿化百分比和灰分密度方面存在显著差异（p < 0.05）。QCT似乎是测量马软骨下骨骨密度的一种良好方法。此外，马第三掌骨远端轴向和背侧软骨下骨密度存在差异。
