具有增强选择性的富含赖氨酸的天蚕素-蜂毒素抗菌肽。
Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity.
作者信息
Sato Hiromi, Feix Jimmy B
机构信息
Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Disease, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
出版信息
Antimicrob Agents Chemother. 2008 Dec;52(12):4463-5. doi: 10.1128/AAC.00810-08. Epub 2008 Oct 13.
Abstract
Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA(1-7) M(2-9) (designated CM15), designed with optimized amphipathicity, retained antimicrobial activities similar to that of wild-type CM15 and had substantially reduced levels of hemolytic activity and cytotoxicity toward cultured macrophages, resulting in enhanced selectivity. These lysine-enriched analogs provide templates for improved CM15 peptide or peptidomimetic antibiotics.
摘要
富含赖氨酸的天蚕素-蜂毒素杂合肽CA(1-7)M(2-9)（命名为CM15）的类似物，通过优化两亲性设计而成，保留了与野生型CM15相似的抗菌活性，并且对培养的巨噬细胞的溶血活性和细胞毒性水平大幅降低，从而提高了选择性。这些富含赖氨酸的类似物为改进CM15肽或拟肽抗生素提供了模板。
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