Rios Oswaldo Angel Bellido, Duprat Andre de Campos, Santos Adriana Ribeiro dos
Santa Casa de São Paulo.
Braz J Otorhinolaryngol. 2008 Jul-Aug;74(4):487-93. doi: 10.1016/s1808-8694(15)30593-0.
UNLABELLED: Larynx is extremely sensitive to endocrinologic changes. Most vocal fold mucosa alterations are caused by changes in vocal fold liquid content and its epithelial changes. Estrogen and progesterone interfere and change this liquid content in the vocal folds. Our goal with the present paper is to study the presence of estrogen and progesterone receptors on vocal fold epithelium in 19 vocal fold epithelium specimens that did not present any indication of disease, especially inflammatory disease. We discarded those cases of patients above 40 years of age and those below 15. RESULTS: We found progesterone receptors in 18 of the 19 patients. The progesterone receptors are located both in the nucleus and the cytoplasm of cells, and mainly in the basal layer. There was no report of estrogen receptors present in the vocal folds. CONCLUSION: Vocal fold epithelium bears progesterone receptors, in the cytoplasm and in the nucleus. We did not find estrogen receptors in the epithelia of the vocal folds investigated.
未标注:喉部对内分泌变化极为敏感。大多数声带黏膜改变是由声带液体含量及其上皮变化引起的。雌激素和孕激素会干扰并改变声带中的这种液体含量。我们撰写本文的目的是研究19个未出现任何疾病迹象(尤其是炎症性疾病)的声带上皮标本中雌激素和孕激素受体的存在情况。我们排除了40岁以上和15岁以下患者的病例。 结果:我们在19名患者中的18名中发现了孕激素受体。孕激素受体位于细胞核和细胞质中,主要在基底层。声带中未发现雌激素受体的报告。 结论:声带上皮在细胞质和细胞核中都含有孕激素受体。在所研究的声带上皮中未发现雌激素受体。
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