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女性声带上皮中雌激素和孕激素受体的免疫组织化学检测

Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia.

作者信息

Rios Oswaldo Angel Bellido, Duprat Andre de Campos, Santos Adriana Ribeiro dos

机构信息

Santa Casa de São Paulo.

出版信息

Braz J Otorhinolaryngol. 2008 Jul-Aug;74(4):487-93. doi: 10.1016/s1808-8694(15)30593-0.


DOI:10.1016/s1808-8694(15)30593-0
PMID:18852972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9442059/
Abstract

UNLABELLED: Larynx is extremely sensitive to endocrinologic changes. Most vocal fold mucosa alterations are caused by changes in vocal fold liquid content and its epithelial changes. Estrogen and progesterone interfere and change this liquid content in the vocal folds. Our goal with the present paper is to study the presence of estrogen and progesterone receptors on vocal fold epithelium in 19 vocal fold epithelium specimens that did not present any indication of disease, especially inflammatory disease. We discarded those cases of patients above 40 years of age and those below 15. RESULTS: We found progesterone receptors in 18 of the 19 patients. The progesterone receptors are located both in the nucleus and the cytoplasm of cells, and mainly in the basal layer. There was no report of estrogen receptors present in the vocal folds. CONCLUSION: Vocal fold epithelium bears progesterone receptors, in the cytoplasm and in the nucleus. We did not find estrogen receptors in the epithelia of the vocal folds investigated.

摘要

未标注:喉部对内分泌变化极为敏感。大多数声带黏膜改变是由声带液体含量及其上皮变化引起的。雌激素和孕激素会干扰并改变声带中的这种液体含量。我们撰写本文的目的是研究19个未出现任何疾病迹象(尤其是炎症性疾病)的声带上皮标本中雌激素和孕激素受体的存在情况。我们排除了40岁以上和15岁以下患者的病例。 结果:我们在19名患者中的18名中发现了孕激素受体。孕激素受体位于细胞核和细胞质中,主要在基底层。声带中未发现雌激素受体的报告。 结论:声带上皮在细胞质和细胞核中都含有孕激素受体。在所研究的声带上皮中未发现雌激素受体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/e437b54ee1bd/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/5341fca97bd9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/1034c3c2c68d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/cb067f21ec55/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/e437b54ee1bd/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/5341fca97bd9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/1034c3c2c68d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/cb067f21ec55/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/9442059/e437b54ee1bd/gr4.jpg

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Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia.

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引用本文的文献

[1]
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Indian J Otolaryngol Head Neck Surg. 2022-12

[2]
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[3]
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[4]
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[5]
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本文引用的文献

[1]
Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats.

Exp Neurol. 2006-4

[2]
Regulation of the immunoexpression of aquaporin 9 by ovarian hormones in the rat oviductal epithelium.

Am J Physiol Cell Physiol. 2005-5

[3]
Estrogen receptor analysis for breast cancer: current issues and keys to increasing testing accuracy.

Adv Anat Pathol. 2005-1

[4]
Regulation of angiogenic activity of human endometrial endothelial cells in culture by ovarian steroids.

J Clin Endocrinol Metab. 2004-11

[5]
Direct effects of sex steroid hormones on adipose tissues and obesity.

Obes Rev. 2004-11

[6]
Proliferation patterns in the canine endometrium during the estrous cycle.

Theriogenology. 2004-8

[7]
Fulvestrant: a review of its use in hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy.

Drugs. 2004

[8]
Identification and characterization of extracellular matrix metalloproteinase inducer in human endometrium during the menstrual cycle in vivo and in vitro.

J Clin Endocrinol Metab. 2003-12

[9]
Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.

J Pathol. 2003-10

[10]
Aquaporin water channel genes are differentially expressed and regulated by ovarian steroids during the periimplantation period in the mouse.

Endocrinology. 2003-4

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