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[巴西东北部一家三级医院的念珠菌血症]

[Candidemia in a tertiary hospital in northeastern Brazil].

作者信息

Hinrichsen Sylvia Lemos, Falcão Erika, Vilella Tatiana Aguiar Santos, Colombo Arnaldo Lopes, Nucci Márcio, Moura Líbia, Rêgo Leandro, Lira Conceição, Almeida Luciano

机构信息

Núcleo de Ensino, Pesquisa e Assistência em Infectologia, Universidade Federal de Pernambuco, Recife, PE.

出版信息

Rev Soc Bras Med Trop. 2008 Jul-Aug;41(4):394-8. doi: 10.1590/s0037-86822008000400014.

Abstract

We conducted a prospective, observational, laboratory-based study on candidemia to investigate the incidence of candidemia, species distribution and clinical conditions between September 2003 and March 2004 in a private tertiary hospital in Recife, northeastern Brazil. Cases of candidemia were defined as occurrences of isolation of Candida spp from blood cultures. The incidence rate was calculated per 1,000 admissions. A total of 5,532 patients were admitted to the hospital during the study period, and 1,745 blood cultures were processed. Twenty-one episodes of candidemia were observed in 18 patients. The incidence rate of candidemia was 3.9 episodes per 1,000 admissions. Non-albicans species accounted for more than 50% of the cases, and Candida parapsilosis (33%) and Candida tropicalis (24%) predominated. Eleven (61%) patients died. The incidence of candidemia was higher than that observed in a Brazilian multicenter study. Candidemia was caused predominantly by non-albicans species.

摘要

我们在巴西东北部累西腓的一家私立三级医院开展了一项关于念珠菌血症的前瞻性、观察性、基于实验室的研究,以调查2003年9月至2004年3月期间念珠菌血症的发病率、菌种分布及临床情况。念珠菌血症病例定义为血培养分离出念珠菌属。发病率按每1000例入院计算。研究期间共有5532例患者入院,共进行了1745次血培养。在18例患者中观察到21次念珠菌血症发作。念珠菌血症的发病率为每1000例入院3.9次发作。非白色念珠菌占病例的50%以上,近平滑念珠菌(33%)和热带念珠菌(24%)占主导。11例(61%)患者死亡。念珠菌血症的发病率高于巴西多中心研究中观察到的发病率。念珠菌血症主要由非白色念珠菌引起。

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