Aquino Renata Telles Rudge de, Vergueiro Carmen Silvia Vieitas, Magliari Maria Elisa Ruffolo, de Freitas Thais Helena Proença
Department of Internal Medicine, Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, Brazil.
Sao Paulo Med J. 2008 Jul;126(4):225-6. doi: 10.1590/s1516-31802008000400006.
DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a type of drug reaction commonly mistaken for a viral infection. It must be recognized promptly due to its high morbidity and 10% mortality rate. Few cases of DRESS syndrome induced by sulfasalazine have been reported in the literature.
The case of a 47-year-old white Brazilian woman who developed DRESS syndrome eight weeks after starting a course of sulfasalazine for treatment of seronegative arthritis is reported. She presented a skin rash, fever, hepatitis, lymphadenopathy, eosinophilia and atypical lymphocytes. The causative drug was discontinued immediately, but she only improved after treatment with prednisone.
药物超敏反应伴嗜酸性粒细胞增多和全身症状综合征（DRESS综合征）是一种常被误诊为病毒感染的药物反应。因其高发病率和10%的死亡率，必须及时识别。文献中鲜有关于柳氮磺胺吡啶诱发DRESS综合征的病例报道。
报道了一名47岁的巴西白人女性病例，该患者在开始使用柳氮磺胺吡啶治疗血清阴性关节炎8周后出现DRESS综合征。她出现了皮疹、发热、肝炎、淋巴结病、嗜酸性粒细胞增多和非典型淋巴细胞。致病药物立即停用，但她在接受泼尼松治疗后才有所好转。
