Wozel Gottfried, Vitéz Lilla, Meurer Michael
Department of Dermatology, Carl Gustav Carus University Hospital, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
Acta Dermatovenerol Alp Pannonica Adriat. 2008 Sep;17(3):133-6.
Palmoplantar pustular psoriasis (PPP) is a chronic inflammatory skin condition mainly characterized by recurrent eruptions of sterile pustules on erythematous skin; hyperkeratosis and fissures on the palms and soles are additional clinical features. Treatment options for PPP are unsatisfactory. We present a patient with a typical course of PPP that had previously received a broad range of topical and systemic antipsoriatic therapies. They all had to be discontinued due to ineffectiveness or side effects. Being aware of the high efficacy of infliximab in generalized pustular psoriasis, we initiated this therapy. An initial improvement was followed by a substantial flare after 7 months, during which a combination treatment of infliximab with methotrexate was administered. Only subsequent monotherapy with efalizumab led to complete clearing up of PPP after 10 to 12 weeks of treatment without any adverse effects. This indicates that efalizumab is potentially effective in PPP.
掌跖脓疱型银屑病（PPP）是一种慢性炎症性皮肤病，主要特征为在红斑皮肤上反复出现无菌性脓疱；手掌和脚底的角化过度及裂隙是其额外的临床特征。PPP的治疗选择并不理想。我们报告一位患有典型PPP病程的患者，该患者此前接受过多种局部和全身性抗银屑病治疗。由于无效或出现副作用，所有这些治疗都不得不中断。鉴于英夫利昔单抗在泛发性脓疱型银屑病中疗效显著，我们启动了该治疗。初始治疗有改善，但7个月后病情大幅复发，在此期间采用了英夫利昔单抗与甲氨蝶呤的联合治疗。仅随后使用依法利珠单抗单药治疗，在治疗10至12周后PPP完全清除，且无任何不良反应。这表明依法利珠单抗在PPP中可能有效。
