Sendur Omer Faruk, Turan Yasemin, Tastaban Engin, Yenisey Cigdem, Serter Mukadder
Department of Physical Medicine and Rehabilitation, Adnan Menderes University Medicine School Hospital, Aydin, Turkey.
Rheumatol Int. 2009 Apr;29(6):629-33. doi: 10.1007/s00296-008-0738-x. Epub 2008 Oct 14.
We proposed to assess antioxidant status and nitric oxide in fibromyalgia (FM) patients in comparison to healthy controls. Additionally, the association between the serum antioxidant levels and clinical findings in FM patients was also investigated. Thirty-seven FM patients and 37 healthy controls were enrolled in this study. Severity of fatigue and pain were determined by Visual Analogue Scale. Functional capacity in daily living activities was evaluated by fibromyalgia impact questionnaire. Serum NO, catalase and glutathione were measured. Serum glutathione and catalase levels were significantly lower in FM patients than controls. However, no significant difference was seen in serum NO levels between the two groups. A significant correlation was evident between serum NO level and pain. Additionally, the correlation between glutathione level and morning stiffness was found to be significant. These findings support other studies, we assume that these two antioxidants might have impact on the pathogenesis of FM disease.
我们建议评估纤维肌痛（FM）患者与健康对照者的抗氧化状态和一氧化氮水平。此外，还研究了FM患者血清抗氧化水平与临床发现之间的关联。本研究纳入了37例FM患者和37例健康对照者。通过视觉模拟量表确定疲劳和疼痛的严重程度。通过纤维肌痛影响问卷评估日常生活活动中的功能能力。检测血清一氧化氮、过氧化氢酶和谷胱甘肽水平。FM患者血清谷胱甘肽和过氧化氢酶水平显著低于对照组。然而，两组血清一氧化氮水平未见显著差异。血清一氧化氮水平与疼痛之间存在显著相关性。此外，发现谷胱甘肽水平与晨僵之间的相关性显著。这些发现支持了其他研究，我们推测这两种抗氧化剂可能对FM疾病的发病机制有影响。
