促红细胞生成素和生长因子在小鼠心脏中表现出不同的血管生成潜力。
Erythropoietin and growth factors exhibit differential angiogenic potential in mouse heart.
作者信息
Pagonopoulou Olga, Efthimiadou Anna, Lambropoulou Maria, Papadopoulos Nikos, Nikolettos Nikos K
机构信息
Department of Physiology, Democritus University of Thrace, Medical School, Alexandroupolis, 68100, Greece.
出版信息
In Vivo. 2008 Sep-Oct;22(5):587-91.
BACKGROUND
The possible angiogenic effect of recombinant human erythropoietin (rHuEpo) and several possibly angiogenic cytokines such as basic fibroblast growth factor (bFGF), acidic fibroblast growth factor (aFGIF) and vascular endothelial growth factor (VEGF) was investigated in mouse heart.
MATERIALS AND METHODS
Mice were divided into five groups (n = 7/group): A, control; B, rHuEpo-treated; C, (aFGF-treated); D, (VEGF-treated); E, (bFGF-treated). The antibody mouse anti-human CD31 was used to evaluate the vessels present in histological preparations.
RESULTS
The results show a significant increase of the vessel number per optical field in the rHuEpo-treated, the bFGF-treated and the VEGF-treated animals compared to controls whereas aFGF did not show any significant angiogenic activity.
CONCLUSION
Erythropoietin has a significant angiogenic effect in the mouse heart, similar to the effect of other angiogenic factors such as bFGF and VEGF whereas aFGF does not exhibit any effect.
背景
在小鼠心脏中研究了重组人促红细胞生成素（rHuEpo）以及几种可能具有血管生成作用的细胞因子，如碱性成纤维细胞生长因子（bFGF）、酸性成纤维细胞生长因子（aFGIF）和血管内皮生长因子（VEGF）的潜在血管生成作用。
材料与方法
将小鼠分为五组（每组n = 7）：A组为对照组；B组为rHuEpo处理组；C组为（aFGF处理组）；D组为（VEGF处理组）；E组为（bFGF处理组）。使用小鼠抗人CD31抗体评估组织学标本中的血管。
结果
结果显示，与对照组相比，rHuEpo处理组、bFGF处理组和VEGF处理组动物每个视野中的血管数量显著增加，而aFGF未显示出任何显著的血管生成活性。
结论
促红细胞生成素在小鼠心脏中具有显著的血管生成作用，类似于bFGF和VEGF等其他血管生成因子的作用，而aFGF没有任何作用。
Zotero 插件