Möller Winfried, Schuschnig Uwe, Meyer Gabriele, Mentzel Heribert, Keller Manfred
Clinical Cooperation Group, Inflammatory Lung Diseases', Helmholtz Center Munich--German Research Center for Environmental Health, Gauting, Germany
Rhinology. 2008 Sep;46(3):213-20.
Although there is a high incidence of nasal disorders including chronic sinusitis, there is limited success in the topical drug delivery to the nose and the paranasal sinuses. This is caused by the nose being an efficient filter for inhaled aerosol particles and the paranasal sinuses being virtually non ventilated
The objective of this study was to visualize the efficiency of sinus ventilation in a nasal cast using dynamic 81mKr-gas imaging in combination with pulsating airflows. Furthermore, the efficiency of the deposition of radiolabelled aerosol was assessed.
Pulsation increased ventilation efficiency of the sinuses more than fivefold and aerosol deposition efficiency more than twentyfold, compared to delivery without pulsation. Furthermore pulsation increased aerosol deposition in the nasal airways by a factor of three. Using pulsating airflow Kr-gas ventilation and aerosol deposition efficiencies increased with increasing sinus volume. Pulsating airflow resulted in a deposition of up to 8% of the nebulized drug within the sinuses compared to 0.2% without pulsation.
The study demonstrates the high efficiency of a pulsating airflow in paranasal sinus ventilation and aerosolized drug delivery. This proves that topical drug delivery to the paranasal sinuses in relevant quantities is possible.
尽管包括慢性鼻窦炎在内的鼻腔疾病发病率很高，但鼻和鼻窦的局部药物递送成功率有限。这是因为鼻子是吸入气溶胶颗粒的高效过滤器，而鼻窦实际上是不通风的。
本研究的目的是使用动态81mKr气体成像结合脉动气流来观察鼻模型中鼻窦通气的效率。此外，还评估了放射性标记气溶胶的沉积效率。
与无脉动递送相比，脉动使鼻窦的通气效率提高了五倍多，气溶胶沉积效率提高了二十倍多。此外，脉动使鼻气道中的气溶胶沉积增加了两倍。使用脉动气流时，Kr气体通气和气溶胶沉积效率随鼻窦体积的增加而提高。与无脉动时的0.2%相比，脉动气流导致高达8%的雾化药物沉积在鼻窦内。
该研究证明了脉动气流在鼻窦通气和气溶胶药物递送方面的高效率。这证明向鼻窦递送相关量的局部药物是可能的。
