Colebunders B, Claes G, Vlieghe E, Demeester R, Moerman F, Colebunders R
University of Antwerp, Antwerp, Belgium.
Rhinology. 2008 Sep;46(3):243-5.
We describe a 55-year-old bisexual Belgian man with a multi-drug resistant HIV infection who developed an Immune Reconstitution Inflammatory Syndrome (IRIS) presenting as a mucocele of the frontal sinus, one year after starting a new effective darunavir containing antiretroviral treatment regimen. His CD4+ lymphocyte count had increased from 3 cells/mm3 prior to the start of the latter treatment to 196 cells/mm3 just before he developed the IRIS phenomenon. IRIS is a paradoxical clinical deterioration during highly active antiretroviral treatment (HAART), due to an exaggerated immune-inflammatory reaction. With the increasing numbers of persons living with HIV infection and the increased use of HAART it is expected that in the future more otolaryngological manifestations of IRIS will be detected.
我们描述了一名55岁的双性恋比利时男性，他患有多重耐药性HIV感染，在开始使用含达芦那韦的新的有效抗逆转录病毒治疗方案一年后，出现了免疫重建炎症综合征（IRIS），表现为额窦黏液囊肿。他的CD4 +淋巴细胞计数从开始后一种治疗前的3个细胞/mm³增加到出现IRIS现象前的196个细胞/mm³。IRIS是高效抗逆转录病毒治疗（HAART）期间出现的一种矛盾的临床恶化情况，是由于免疫炎症反应过度所致。随着感染HIV的人数不断增加以及HAART的使用增多，预计未来将检测到更多IRIS的耳鼻喉科表现。
