UDP-N-乙酰-D-半乳糖胺：多肽N-乙酰半乳糖胺基转移酶-6在胃黏膜、肠化生及胃癌中的表达
Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma.
作者信息
Gomes Joana, Marcos Nuno T, Berois Nora, Osinaga Eduardo, Magalhães Ana, Pinto-de-Sousa João, Almeida Raquel, Gärtner Fátima, Reis Celso A
机构信息
Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal.
出版信息
J Histochem Cytochem. 2009 Jan;57(1):79-86. doi: 10.1369/jhc.2008.952283. Epub 2008 Oct 14.
Abstract
Aberrant mucin O-glycosylation is often observed in cancer and is characterized by the expression of immature simple mucin-type carbohydrate antigens. UDP-N-acetyl-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6) is one of the enzymes responsible for the initial step in O-glycosylation. This study evaluated the expression of ppGalNAc-T6 in human gastric mucosa, intestinal metaplasia, and gastric carcinomas. Our results showed that ppGalNAc-T6 is expressed in normal gastric mucosa and in intestinal metaplasia. A heterogeneous expression and staining pattern for this enzyme was observed in gastric carcinomas. ppGalNAc-T6 was expressed in 79% of the cases, and its expression level was associated with the presence of venous invasion. Our results provide evidence that ppGalNAc-T6 is an IHC marker associated with venous invasion in gastric carcinoma and may contribute to the understanding of the molecular mechanisms that underlie aberrant glycosylation in gastric carcinogenesis and in gastric carcinoma.
摘要
异常的粘蛋白O-糖基化在癌症中经常被观察到，其特征是未成熟的简单粘蛋白型碳水化合物抗原的表达。UDP-N-乙酰-d-半乳糖胺：多肽N-乙酰半乳糖胺基转移酶-6（ppGalNAc-T6）是负责O-糖基化第一步的酶之一。本研究评估了ppGalNAc-T6在人胃黏膜、肠化生和胃癌中的表达。我们的结果表明，ppGalNAc-T6在正常胃黏膜和肠化生中表达。在胃癌中观察到该酶的异质性表达和染色模式。ppGalNAc-T6在79%的病例中表达，其表达水平与静脉侵犯的存在相关。我们的结果提供了证据，表明ppGalNAc-T6是一种与胃癌静脉侵犯相关的免疫组化标志物，可能有助于理解胃癌发生和胃癌中异常糖基化的分子机制。
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本文引用的文献
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Virchows Arch. 2007 Oct;451(4):805-14. doi: 10.1007/s00428-007-0478-4. Epub 2007 Aug 11.
2
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Acta Histochem. 2007;109(4):273-84. doi: 10.1016/j.acthis.2007.02.009. Epub 2007 Apr 19.
3
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4
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10
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