Dejana Elisabetta, Orsenigo Fabrizio, Molendini Cinzia, Baluk Peter, McDonald Donald M
IFOM , FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
Cell Tissue Res. 2009 Jan;335(1):17-25. doi: 10.1007/s00441-008-0694-5. Epub 2008 Oct 15.
Adhesive intercellular junctions between endothelial cells are formed by tight junctions and adherens junctions. In addition to promoting cell-to-cell adhesion, these structures regulate paracellular permeability, contact inhibition of endothelial cell growth, cell survival, and maintenance of cell polarity. Furthermore, adherens junctions are required for the correct organization of new vessels during embryo development or during tissue proliferation in the adult. Extensive research on cultured epithelial and endothelial cells has resulted in the identification of many molecular components of tight junctions and adherens junctions. Such studies have revealed the complexity of these structures, which are formed by membrane-associated adhesion proteins and a network of several intracellular signaling partners. This review focuses on the structural organization of junctional structures and their functional interactions in the endothelium of blood vessels and lymphatics. We emphasize the way that these structures regulate endothelial cell homeostasis by transferring specific intracellular signals and by modulating activation and signaling of growth factor receptors.
内皮细胞之间的黏附性细胞连接由紧密连接和黏着连接形成。除了促进细胞间黏附外，这些结构还调节细胞旁通透性、内皮细胞生长的接触抑制、细胞存活以及细胞极性的维持。此外，在胚胎发育期间或成体组织增殖过程中，新血管的正确组织需要黏着连接。对培养的上皮细胞和内皮细胞的广泛研究已鉴定出紧密连接和黏着连接的许多分子成分。此类研究揭示了这些结构的复杂性，它们由膜相关黏附蛋白和几个细胞内信号转导伙伴网络组成。本综述重点关注血管和淋巴管内皮中连接结构的组织结构及其功能相互作用。我们强调这些结构通过传递特定的细胞内信号以及调节生长因子受体的激活和信号转导来调节内皮细胞稳态的方式。
