Suhm Norbert, Lamy Olivia, Lippuner Kurt
Treatment Centre for Musculoskeletal Diseases, University Hospital of Basel, Basel, Switzerland.
Swiss Med Wkly. 2008 Nov 15;138(45-46):674-83. doi: 10.4414/smw.2008.12294.
A nationwide survey was conducted in Switzerland to assess the quality level of osteoporosis management in patients aged 50 years or older presenting with a fragility fracture to the emergency ward of the participating hospitals. Eight centres recruited 4966 consecutive patients who presented with one or more fractures between 2004 and 2006. Of these, 3667 (2797 women, 73.8 years old and 870 men, 73.0 years old in average) were considered as having a fragility fracture and included in the survey. Included patients presented with a fracture of the upper limbs (30.7%), lower limbs (26.4%), axial skeleton (19.5%) or another localisation, including malleolar fractures (23.4%). Thirty-two percent reported one or more previous fractures during adulthood. Of the 2941 (80.2%) hospitalised women and men, only half returned home after discharge. During diagnostic workup, dual x-ray absorptiometry (DXA) measurement was performed in 31.4% of the patients only. Of those 46.0% had a T-score < or =-2.5 SD and 81.1% < or =-1.0 SD. Osteoporosis treatment rate increased from 26.3% before fracture to 46.9% after fracture in women and from 13.0% to 30.3% in men. However, only 24.0% of the women and 13.8% of the men were finally adequately treated with a bone active substance, generally an oral bisphosphonate, with or without calcium / vitamin D supplements. A positive history of previous fracture vs none increased the likelihood of getting treatment with a bone active substance (36.6 vs 17.9%, ? 18.7%, 95% CI 15.1 to 22.3, and 22.6 vs 9.9%, ? 12.7%, CI 7.3 to 18.5, in women and men, respectively). In Switzerland, osteoporosis remains underdiagnosed and undertreated in patients aged 50 years and older presenting with a fragility fracture.
在瑞士开展了一项全国性调查,以评估50岁及以上因脆性骨折前往参与调查医院急诊科就诊的患者的骨质疏松症管理质量水平。八个中心招募了2004年至2006年间连续出现一处或多处骨折的4966名患者。其中,3667名(2797名女性,平均年龄73.8岁;870名男性,平均年龄73.0岁)被视为脆性骨折患者并纳入调查。纳入的患者上肢骨折占30.7%,下肢骨折占26.4%,轴向骨骼骨折占19.5%,或其他部位骨折,包括踝关节骨折占23.4%。32%的患者报告成年期有一处或多处既往骨折。在2941名(80.2%)住院的女性和男性中,出院后只有一半回家。在诊断检查过程中,仅31.4%的患者进行了双能X线吸收法(DXA)测量。其中,46.0%的患者T值≤-2.5标准差,81.1%的患者≤-1.0标准差。女性骨质疏松症治疗率从骨折前的26.3%升至骨折后的46.9%,男性从13.0%升至30.3%。然而,最终只有24.0%的女性和13.8%的男性接受了骨活性物质的充分治疗,通常是口服双膦酸盐,加或不加钙/维生素D补充剂。有既往骨折史与无骨折史相比,接受骨活性物质治疗的可能性增加(女性为36.6%对17.9%,差值18.7%,95%置信区间15.1至22.3;男性为22.6%对9.9%,差值12.7%,置信区间7.3至18.5)。在瑞士,50岁及以上因脆性骨折就诊的患者中,骨质疏松症仍未得到充分诊断和治疗。