Aguado-Maestro Ignacio, Panteli Michalis, García-Alonso Manuel, Bañuelos-Díaz Alejandro, Giannoudis Peter V
Traumatology and Orthopaedic Surgery Department, Hospital Universitario del Río Hortega, C Dulzaina 2, Valladolid, Spain; Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Clarendon Wing, Level A, Great George Street, Leeds, UK.
Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Clarendon Wing, Level A, Great George Street, Leeds, UK.
Injury. 2017 Dec;48 Suppl 7:S27-S33. doi: 10.1016/j.injury.2017.08.035. Epub 2017 Aug 26.
Our aim was to investigate whether patients presenting with fragility fractures of the proximal femur are receiving osteoporosis treatment and to assess the number of other fragility fractures they have sustained prior to admission.
All patients presenting to our institution with fragility fractures of the proximal femur within an 18-month period (January 2012-August 2013) were included. Patient demographics; fracture classification (AO/OTA); American Society of Anesthesiologists (ASA) grade; Abbreviated Mental Test Score (AMTS) on admission; type of operation; time to operation; peri-operative complications; length of hospital stay (LOS); walking status; osteoporotic medication; Dual-energy X-ray absorptiometry (DEXA) results; additional fragility fractures; and mortality were collected and analysed.
A total of 1004 patients (278 male) met the inclusion criteria and were included into the study. The mean age was 82.01 years and mean LOS was 19.54days. Fifty-four per cent of the patients were admitted from their own homes whereas 43% were capable to walk indoors without any aids before their injury. Mean time to surgery was 2.06days (Median: 1.31, range: 0-26days). Three hundred and six patients (30.5%) had at least another fragility fracture before the index episode (mean 1.40 fractures; SD: 0.71 fractures; range: 1-6 fractures). Only 16.4% were under complete osteoporosis treatment on admission, defined as receiving calcium with vitamin D and a bisphosphonate or an alternative agent. When we compared patients without a history of a previous fragility fracture (Group A) and patients with at least another previous fragility fracture (Group B), we found that patients in Group B had a significantly lower AMTS score, lower bone mineral density (BMD) as evident on the DEXA scan, an inferior mobility before admission and a higher incidence of extracapsular fractures (p<0.05). On discharge, patients in Group B had a higher chance of receiving complete bone protection compared to group A (27.9% versus 41.7%; p<0.01). Following discharge, 11.2% of the patients sustained an additional fragility fracture. The mean time from the index episode to the additional fracture was 0.65 years, whilst these injuries were more frequent in Group B (RR=1.638; p<0.05).
Patients presenting with a hip fracture are generally under-treated for osteoporosis. Post-operative assessment by a designated geriatrician and use of a standardised protocol is of paramount importance for reducing the risk of additional fragility fractures. Additionally, screening of the elderly population for identifying the patients who suffer from osteoporosis can potentially reduce the risk of sustaining a further fragility fracture.
我们的目的是调查股骨近端脆性骨折患者是否正在接受骨质疏松症治疗,并评估他们在入院前发生的其他脆性骨折的数量。
纳入在18个月期间(2012年1月至2013年8月)因股骨近端脆性骨折前来我院就诊的所有患者。收集并分析患者的人口统计学资料、骨折分类(AO/OTA)、美国麻醉医师协会(ASA)分级、入院时简易精神状态检查表(AMTS)评分、手术类型、手术时间、围手术期并发症、住院时间(LOS)、行走状态、骨质疏松症用药、双能X线吸收法(DEXA)结果、其他脆性骨折情况以及死亡率。
共有1004例患者(278例男性)符合纳入标准并被纳入研究。平均年龄为82.01岁,平均住院时间为19.54天。54%的患者从家中入院,43%的患者在受伤前能够在室内无需辅助自行行走。平均手术时间为2.06天(中位数:1.31天,范围:0 - 26天)。306例患者(30.5%)在本次骨折事件之前至少还有一次脆性骨折(平均1.40次骨折;标准差:0.71次骨折;范围:1 - 6次骨折)。入院时仅有16.4%的患者接受了完整的骨质疏松症治疗,完整的骨质疏松症治疗定义为同时服用钙和维生素D以及一种双膦酸盐或其他替代药物。当我们比较无既往脆性骨折病史的患者(A组)和至少有一次既往脆性骨折的患者(B组)时,我们发现B组患者的AMTS评分显著更低,DEXA扫描显示骨密度(BMD)更低,入院前活动能力较差,且囊外骨折发生率更高(p<0.05)。出院时,B组患者接受完整骨骼保护的可能性高于A组(27.9%对41.7%;p<0.01)。出院后,11.2%的患者发生了额外的脆性骨折。从本次骨折事件到再次骨折的平均时间为0.65年,而这些损伤在B组中更为常见(相对危险度=1.638;p<0.05)。
髋部骨折患者的骨质疏松症治疗普遍不足。由指定的老年病科医生进行术后评估并采用标准化方案对于降低额外脆性骨折的风险至关重要。此外,对老年人群进行筛查以识别患有骨质疏松症的患者可能会降低再次发生脆性骨折的风险。