Korkmaz Ahmet, Topal Turgut, Oter Sukru, Tan Dun-Xian, Reiter Russel J
Gulhane Askeri Tip Akademisi, Fizyoloji Anabilim Dali, 06018 Ankara, Turkey.
Mini Rev Med Chem. 2008 Oct;8(11):1144-53. doi: 10.2174/138955708785909925.
Chronically-elevated blood glucose initiates a harmful series of processes in which toxic reactive species play crucial roles. Oxidative as well as nitro-oxidative stress is harmful for virtually all biomolecules including lipids, proteins and DNA. Such pathophysiologic mechanisms eventually results in cellular dysfunction, apoptosis or necrosis. Melatonin is a multifunctional indolamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity. These are related to melatonin's antioxidative, anti-inflammatory and possibly epigenetic regulatory properties. Current knowledge encourages using this non-toxic indolamine either as a sole treatment or in conjunction with other treatments for inhibition of the biohazards of hyperglycemia.
长期血糖升高会引发一系列有害过程，其中有毒活性物质起着关键作用。氧化应激以及硝基氧化应激实际上对包括脂质、蛋白质和DNA在内的所有生物分子都有害。这种病理生理机制最终会导致细胞功能障碍、凋亡或坏死。褪黑素是一种多功能吲哚胺，它可以对抗多个病理生理步骤，并对高血糖诱导的细胞毒性显示出显著的有益作用。这些作用与褪黑素的抗氧化、抗炎以及可能的表观遗传调节特性有关。目前的知识鼓励将这种无毒吲哚胺单独使用或与其他治疗方法联合使用，以抑制高血糖的生物危害。
