Neudert Franziska, Nuernberger Krishna-K Monique, Redies Christoph
Institute of Anatomy I, University of Jena School of Medicine, D-07740 Jena, Germany.
J Comp Neurol. 2008 Dec 20;511(6):736-52. doi: 10.1002/cne.21865.
The cerebellum shows remarkable variations in the relative size of its divisions among vertebrate species. In the present study, we compare the cerebella of two mammals (ferret and mouse) by mapping the expression of three cadherins (cadherin-8, protocadherin-7, and protocadherin-10) at similar postnatal stages. The three cadherins are expressed differentially in parasagittal stripes in the cerebellar cortex, in the portions of the deep cerebellar nuclei, in the divisions of the inferior olivary nucleus, and in the lateral vestibular nucleus. The expression profiles suggest that the cadherin-positive structures are interconnected. The expression patterns resemble each other in ferret and mouse, although some differences can be observed. The general resemblance indicates that cerebellar organization is based on a common set of embryonic divisions in the two species. Consequently, the large differences in cerebellar morphology between the two species are more likely caused by differential growth of these embryonic divisions than by differences in early embryonic patterning. Based on the cadherin expression patterns, a model of corticonuclear projection territories in ferret and mouse is proposed. In summary, our results indicate that the cerebellar systems of rodents and carnivores display a relatively large degree of similarity in their molecular and functional organization.
在脊椎动物物种中，小脑各部分的相对大小存在显著差异。在本研究中，我们通过绘制两种哺乳动物（雪貂和小鼠）在相似出生后阶段三种钙黏蛋白（钙黏蛋白-8、原钙黏蛋白-7和原钙黏蛋白-10）的表达图谱，对它们的小脑进行了比较。这三种钙黏蛋白在小脑皮质的矢状旁条纹、小脑深部核团的部分区域、下橄榄核的分区以及外侧前庭核中呈差异表达。表达谱表明钙黏蛋白阳性结构相互连接。雪貂和小鼠的表达模式相似，尽管可以观察到一些差异。总体相似性表明，这两个物种的小脑组织基于一组共同的胚胎分区。因此，这两个物种小脑形态的巨大差异更可能是由这些胚胎分区的差异生长引起的，而不是早期胚胎模式的差异。基于钙黏蛋白的表达模式，我们提出了雪貂和小鼠皮质核投射区域的模型。总之，我们的结果表明，啮齿动物和食肉动物的小脑系统在分子和功能组织上表现出相对较高的相似性。
