Mishima M, Sugiura N, Fukunga T, Kawakami K, Tanaka E, Tsutsui T, Nishimura K, Kuno K
Department of Clinical Physiology, Kyoto University, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 May;29(5):566-72.
The factors which increase phase differences between mouth flow and chest flow in patients with obstructive disorders were analyzed. From airway resistance, thoracic gas volume and measured chest flow, phase difference was predicted by the Runge-Kutta (R.K.) method assuming respiratory system to be a single compartment model. The ratio of the measured phase differences to the predicted value by the R.K. method in normal subjects was 0.99 +/- 0.25. These results suggest that a single compartment model can be applied to normal respiratory system. In contrast, predicted phase differences were remarkably higher than measured values in patients with obstructive disorders (CPE: 1.83 +/- 0.63, DPB: 1.50 +/- 0.48). This phenomenon could be explained by the existence of parallel inhomogeneity of alveolar pressure.
分析了阻塞性疾病患者口腔气流与胸部气流之间相位差增加的因素。根据气道阻力、胸腔气体容积和测量的胸部气流，假设呼吸系统为单室模型，采用龙格 - 库塔（R.K.）方法预测相位差。正常受试者中测量的相位差与R.K.方法预测值的比值为0.99±0.25。这些结果表明单室模型可应用于正常呼吸系统。相比之下，阻塞性疾病患者（慢性阻塞性肺疾病：1.83±0.63，弥漫性泛细支气管炎：1.50±0.48）的预测相位差明显高于测量值。这种现象可以用肺泡压力平行不均匀性的存在来解释。
