Messmer C, Stümpfig D, Flammer J
Kantonsspital Luzern Augenklinik.
Klin Monbl Augenheilkd. 1991 May;198(5):330-1. doi: 10.1055/s-2008-1045972.
In a prospective, randomized, double-masked study, primary open-angle glaucoma patients were treated twice daily with either betaxolol 0.5% or timolol 0.5%. Patients received a pretreatment baseline examination following a 2 week washout period; they were then examined after 3 and 6 months of treatment. Each examination included visual field measurements with an Octopus automated perimeter and intraocular pressure measurement. The visual fields of the betaxolol group showed on the average a pronounced tendency toward improvement (MD decrease of 2.05 dB); visual fields in the timolol group showed a slight tendency toward improvement (MD decrease of 1.56 dB). The difference between these 2 trends after 6 months was statistically not significant (p greater than or equal to 0.05, U-test). Both drugs lowered intraocular pressure, there was no significant difference between the two drugs (p greater than or equal to 0.05, U-test).
在一项前瞻性、随机、双盲研究中，原发性开角型青光眼患者每天接受两次0.5%倍他洛尔或0.5%噻吗洛尔治疗。患者在经过2周的洗脱期后接受治疗前基线检查；然后在治疗3个月和6个月后进行检查。每次检查包括使用Octopus自动视野计进行视野测量和眼压测量。倍他洛尔组的视野平均显示出明显的改善趋势（平均差值降低2.05 dB）；噻吗洛尔组的视野显示出轻微的改善趋势（平均差值降低1.56 dB）。6个月后这两种趋势之间的差异在统计学上不显著（p≥0.05，U检验）。两种药物均降低了眼压，两种药物之间无显著差异（p≥0.05，U检验）。
