Pietschmann P, Niederle B, Anvari A, Woloszczuk W
2. Medizinische Universitätsklinik, Ludwig Boltzmann Institut für Klinische Endokrinologie, Wien, Osterreich.
Klin Wochenschr. 1991 May 24;69(8):351-3. doi: 10.1007/BF02115782.
The serum levels of osteocalcin, a 49-amino-acid bone-matrix protein, have been found to be a specific biochemical parameter of bone formation. The aim of our study was to compare the sensitivity of serum osteocalcin levels with that of alkaline phosphatase in the evaluation of patients with primary hyperparathyroidism. In 40 patients with biochemically and histologically confirmed primary hyperparathyroidism, the serum levels of osteocalcin, intact parathyroid hormone, alkaline phosphatase, calcium, phosphorus, and creatinine were determined preoperatively. The serum levels of osteocalcin were elevated in 22 patients (55%), whereas the serum levels of alkaline phosphatase were increased in 18 patients (45%). In 10 patients (25%) the serum levels of osteocalcin, but not those of alkaline phosphatase, were increased, whereas in six patients the activity of alkaline phosphatase was high, but the serum osteocalcin levels were normal. When the biochemical data of the patients with increased serum osteocalcin levels were compared with those of the patients with serum osteocalcin levels within the normal range, the serum levels of intact parathyroid hormone and alkaline phosphatase were significantly increased in the group of patients with elevated serum osteocalcin levels. Our data indicate that serum osteocalcin levels might be a clinically useful additional parameter in the evaluation of patients with primary hyperparathyroidism.
骨钙素是一种含49个氨基酸的骨基质蛋白，其血清水平已被发现是骨形成的一个特定生化参数。我们研究的目的是在评估原发性甲状旁腺功能亢进患者时，比较血清骨钙素水平和碱性磷酸酶的敏感性。对40例经生化和组织学确诊的原发性甲状旁腺功能亢进患者，术前测定其血清骨钙素、完整甲状旁腺激素、碱性磷酸酶、钙、磷和肌酐水平。22例患者（55%）血清骨钙素水平升高，而18例患者（45%）血清碱性磷酸酶水平升高。10例患者（25%）血清骨钙素水平升高而碱性磷酸酶水平未升高，而6例患者碱性磷酸酶活性高但血清骨钙素水平正常。将血清骨钙素水平升高患者的生化数据与血清骨钙素水平在正常范围内的患者进行比较时，血清骨钙素水平升高组患者的完整甲状旁腺激素和碱性磷酸酶水平显著升高。我们的数据表明，血清骨钙素水平可能是评估原发性甲状旁腺功能亢进患者的一个临床上有用的附加参数。
