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可扩张气管支架治疗手术诱导的仔猪气管软化症的比较

Comparison of expandable endotracheal stents in the treatment of surgically induced piglet tracheomalacia.

作者信息

Mair E A, Parsons D S, Lally K P, Van Dellen A F

机构信息

Section of Pediatric Otolaryngology, Wilford Hall USAF Medical Center, Lackland AFB, TX 78236-5300.

出版信息

Laryngoscope. 1991 Sep;101(9):1002-8. doi: 10.1288/00005537-199109000-00013.

Abstract

Present surgical alternatives for pediatric tracheobronchomalacia are limited and associated with many potentially undesirable complications. The feasibility of different intraluminal expandable endotracheal stents for the treatment of surgically induced tracheomalacia was analyzed in 27 piglets. A potentially fatal tracheomalacia was surgically created. Either a stainless steel "zig-zag" stent or a woven polymeric stent was then implanted. Tracheal patency, mucosal function, histopathologic respiratory tract changes, and effects of the stent on esophageal motility were evaluated over a 16-week period. Piglets with steel stents uniformly experienced intense inflammation leading to tracheal dysfunction and death. Piglets with polymeric stents experienced minimal respiratory symptoms. Expandable polymeric endotracheal stents alleviate surgically induced piglet tracheomalacia, were easy to insert, allowed for tracheal growth, and reduced the need for high-risk surgical procedures with prolonged ventilatory support.

摘要

目前用于小儿气管软化症的外科治疗方法有限,且伴有许多潜在的不良并发症。在27只仔猪中分析了不同腔内可扩张气管支架治疗手术诱发的气管软化症的可行性。通过手术制造出一种可能致命的气管软化症。然后植入不锈钢“之”字形支架或编织聚合物支架。在16周的时间里评估气管通畅性、黏膜功能、组织病理学呼吸道变化以及支架对食管动力的影响。植入钢支架的仔猪均出现严重炎症,导致气管功能障碍和死亡。植入聚合物支架的仔猪呼吸道症状轻微。可扩张聚合物气管支架可缓解手术诱发的仔猪气管软化症,易于插入,允许气管生长,并减少了对需要长期通气支持的高风险外科手术的需求。

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