Floreani A, Chiaramonte M, Fabris P, Naccarato R
Divisione di Gastroenterologia, Istituto di Medicina interna, Università, Padova.
Recenti Prog Med. 1991 May;82(5):259-61.
Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease with onset about menopause. To investigate its clinical features and the natural history in relation to age, we examined 86 consecutive patients with PBC (81 F, 5 M); 70 were less than 65 years (mean age 48 years) and 16 greater than 65 years (mean age 69 years). All patients were followed-up for 6 months-16 years (mean 4 years). Histological stage at presentation was comparable in the two groups, but among aged PBC subjects there was a significantly higher prevalence of asymptomatic patients (56% vs 24%, p less than 0.001). No significant differences were observed in the biochemical indices and immunological abnormalities. Survival curves showed no significant differences in PBC according to the age. Mortality was observed only in the group less than 65 years (15/70, 21.4%). In conclusion, the large proportion of asymptomatic subjects in the elderly PBC patients accounts for the similar survival in the two groups of patients.
原发性胆汁性肝硬化（PBC）是一种约在绝经时发病的慢性胆汁淤积性肝病。为了研究其临床特征及与年龄相关的自然病程，我们对86例连续的PBC患者（81例女性，5例男性）进行了检查；其中70例年龄小于65岁（平均年龄48岁），16例年龄大于65岁（平均年龄69岁）。所有患者均随访6个月至16年（平均4年）。两组患者初诊时的组织学分期相当，但在老年PBC患者中，无症状患者的患病率显著更高（56%对24%，p<0.001）。在生化指标和免疫异常方面未观察到显著差异。生存曲线显示，PBC患者的生存情况按年龄无显著差异。仅在年龄小于65岁的组中观察到死亡（15/70，21.4%）。总之，老年PBC患者中无症状患者比例高，这导致两组患者的生存情况相似。
