FABER H K, SILVERBERG R J, DONG L
J Exp Med. 1948 Jul;88(1):65-72. doi: 10.1084/jem.88.1.65.
36 exposures of the stomach and intestines of 18 cynomolgus monkeys to large doses of poliomyelitis virus by a method designed to avoid simultaneous exposure of the oropharynx and upper esophagus induced poliomyelitis in only one instance. These observations are to be compared with a previous study in which exposures of the entire alimentary tract including oropharynx and upper esophagus by simple feeding of comparable amounts of the same strain resulted in poliomyelitis in half of the test animals. In the capsule-fed animals virus regularly appeared in the stools during and immediately after the feeding periods but disappeared thereafter excepting in the single case of poliomyelitis, in which it persisted. No evidence of resistance to subsequent intracerebral inoculation was observed in the uninfected capsule-fed animals.
通过一种旨在避免口咽和上食管同时接触的方法,对18只食蟹猴的胃和肠道进行了36次大剂量脊髓灰质炎病毒暴露,仅在一例中诱发了脊髓灰质炎。这些观察结果将与之前的一项研究进行比较,在该研究中,通过简单喂食等量的同一毒株使包括口咽和上食管在内的整个消化道接触病毒,导致一半的试验动物患上脊髓灰质炎。在通过胶囊喂食病毒的动物中,病毒在喂食期间和喂食后立即定期出现在粪便中,但此后消失,除了脊髓灰质炎的单一病例,在该病例中病毒持续存在。在未感染的通过胶囊喂食病毒的动物中,未观察到对随后脑内接种有抵抗力的证据。