Schwarzmeier J D, Honetz N, Deutsch E
Haematologia (Budap). 1976;10(1):27-31.
In the cells of acute leukemia the duration of the cell cycle and its phases was determined in vitro by autoradiographic techniques. Tests were run simultaneously for bone marrow and peripheral leukaemic cells and the intracellular levels of cAMP were measured. The results suggest a correlation to exist between cAMP concentration in leukaemic cells and the growth rate of the cell population. Hence, cAMP assays appear to be suited for monitoring cellular proliferation kinetics and could provide a useful parameter for planning cell-phase-specific therapy.
采用放射自显影技术在体外测定急性白血病细胞的细胞周期及其各阶段的持续时间。同时对骨髓细胞和外周白血病细胞进行检测，并测定细胞内cAMP水平。结果表明，白血病细胞中的cAMP浓度与细胞群体的生长速率之间存在相关性。因此，cAMP检测似乎适合监测细胞增殖动力学，并可为制定细胞周期特异性治疗方案提供有用的参数。
