Cesareni G, Helmer-Citterich M, Castagnoli L
Department of Biology, II University of Rome Tor Vergata, Italy.
Trends Genet. 1991 Jul;7(7):230-5. doi: 10.1016/0168-9525(91)90370-6.
One of the two major classes of regulatory strategies that control plasmid copy number involves recognition via base pairing between two plasmid-encoded complementary RNAs. The detailed analysis of this control circuitry has revealed some features of regulatory mechanisms based on RNA-RNA interaction that distinguish them from those based on protein-nucleic acid interaction. These features provide a framework with which to understand other regulatory mechanisms based on RNA-RNA interaction, and will aid in the design of efficient artificial antisense RNA systems.
控制质粒拷贝数的两种主要调控策略之一涉及通过两个质粒编码的互补RNA之间的碱基配对进行识别。对这种控制回路的详细分析揭示了基于RNA-RNA相互作用的调控机制的一些特征，这些特征将它们与基于蛋白质-核酸相互作用的调控机制区分开来。这些特征提供了一个框架，用以理解基于RNA-RNA相互作用的其他调控机制，并将有助于设计高效的人工反义RNA系统。
