辐射防护性巯基烷基胺及其衍生的硫代磷酸盐诱导干扰素生成

Interferon induction by radioprotective mercaptoalkylamines and derived thiophosphates.

作者信息

Lvovsky E, Levy H B, Doherty D G, Baron S

出版信息

Infect Immun. 1977 Jan;15(1):191-6. doi: 10.1128/iai.15.1.191-196.1977.

DOI:10.1128/iai.15.1.191-196.1977

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC421348/

Abstract

Radioprotective thiols (five mercaptoalkylamines and four derived thiophosphates) induced interferon and resistance to virus infection. Interferon production occurred in human and mouse nonlymphoid cell cultures. One of the thiols, S,2-aminoethylisothiourea, given intraperitoneally, protected mice against two unrelated viruses--Semliki forest virus and Herpesvirus hominis type 1. Two structurally different radioprotective thiols--the disulfide cystamine and L-cysteine--were unable to induce the firus resistance state or interferon.

摘要

具有辐射防护作用的硫醇（五种巯基烷基胺和四种衍生硫代磷酸盐）可诱导产生干扰素并增强对病毒感染的抵抗力。干扰素在人和小鼠的非淋巴细胞培养物中产生。其中一种硫醇，即S，2-氨基乙基异硫脲，腹腔注射可保护小鼠免受两种不相关病毒——Semliki森林病毒和1型人疱疹病毒的侵害。两种结构不同的具有辐射防护作用的硫醇——二硫化合物胱胺和L-半胱氨酸——无法诱导产生抗病毒状态或干扰素。

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引用本文的文献

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Radioprotective activity of interferon inducers.干扰素诱导剂的辐射防护活性。

Arch Virol. 1978;56(4):309-15. doi: 10.1007/BF01315281.

本文引用的文献

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Distribution of cystamine-35S in the sub-cellular particles of the organs of the rat.胱胺-35S在大鼠器官亚细胞颗粒中的分布。

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INTERFERON.干扰素

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Chemical protection against ionizing radiation. III. Mercaptoalkylguanidines and related isothiuronium compounds with protective activity.针对电离辐射的化学防护。III. 具有防护活性的巯基烷基胍及相关异硫脲化合物。

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Interferon as an antiviral agent in vivo: quantitative and temporal aspects of the protection of mice against Semliki Forest virus.干扰素作为体内抗病毒剂：小鼠抵抗Semliki森林病毒保护作用的定量和时间方面

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S-2-(omega-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents.S-2-(ω-氨基烷基氨基)乙基硫代磷酸二氢酯及相关化合物作为潜在的抗辐射剂。

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Radioprotective agents: further results with amidophosphorothioate and related compounds.

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Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.干扰素与宿主抗性的诱导剂。II. 多链合成多核苷酸复合物。

Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004-10. doi: 10.1073/pnas.58.3.1004.

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Interferon: its inducers and some aspects of host resistance in malignancy.干扰素：其诱导剂及恶性肿瘤中宿主抵抗力的某些方面。

Cancer Chemother Rep. 1974 Jul-Aug;58(4):571-8.

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Oral induction of interferon by a low-molecular-weight compound.一种低分子量化合物对干扰素的口服诱导作用。

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Improved assays for a variety of interferons. 1.多种干扰素的改良检测方法。1.

Proc Soc Exp Biol Med. 1972 Sep;140(4):1178-81. doi: 10.3181/00379727-140-36636.

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