Sandin R, Feuk U, Wahlberg J, Modig J
Department of Anaesthesiology and Intensive Care, University Hospital, Uppsala, Sweden.
Acta Anaesthesiol Scand. 1991 Jul;35(5):424-9. doi: 10.1111/j.1399-6576.1991.tb03322.x.
Diltiazem--a calcium entry blocker--was tested in a porcine model under continuous chlormethiazole-pancuronium anaesthesia as protection against renal failure following 60 min of renal ischaemia. Fourteen pigs were randomly allocated to one experimental (diltiazem and ischaemia) and one control group (only ischaemia) (n = 7 in each). Diltiazem was administered as a continuous intravenous infusion started before the ischaemic insult. In two additional animals diltiazem was given but ischemia was not induced. The postischaemic renal cortical microcirculation was simultaneously investigated in four different regions in the left kidney during the first 4 h of reperfusion. Laser Doppler flowmetry (LDF) was performed in two different regions and measurement of tissue oxygenation was done in two other regions. In the two animals treated with diltiazem without ischaemia, only minor variations in central haemodynamic and renal microcirculatory parameters were evident. In the control group (ischaemia), superficial renal cortical blood flow (Qsrc) decreased from 49 +/- 11 (s.d.) arbitrary units at baseline to 24 +/- 4 arb. units 4 h after start of reperfusion (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
地尔硫䓬——一种钙通道阻滞剂——在猪模型中，于持续使用氯美噻唑-泮库溴铵麻醉下进行试验，以作为防止肾缺血60分钟后肾衰竭的保护措施。14头猪被随机分为一个试验组（地尔硫䓬和缺血）和一个对照组（仅缺血）（每组n = 7）。地尔硫䓬在缺血性损伤前开始以持续静脉输注给药。另外两只动物给予地尔硫䓬但未诱导缺血。在再灌注的前4小时，同时在左肾的四个不同区域研究缺血后肾皮质微循环。在两个不同区域进行激光多普勒血流测定（LDF），在另外两个区域进行组织氧合测量。在未缺血而接受地尔硫䓬治疗的两只动物中，中心血流动力学和肾微循环参数仅有轻微变化。在对照组（缺血）中，肾皮质浅表血流（Qsrc）从基线时的49±11（标准差）任意单位降至再灌注开始后4小时的24±4任意单位（P<0.05）。（摘要截短于250字）
