Karlsson K K, Flock B, Flock A
Department of Audiology, Huddinge University Hospital, Sweden.
Acta Otolaryngol. 1991;111(3):500-5. doi: 10.3109/00016489109138375.
The outer hair cells have been shown to have motile properties which are likely to participate in the cochlear performance. Quinine is known to induce hearing loss as well as contraction of skeletal muscles. Isolated outer hair cells and isolated cochleae from guinea pigs have been exposed to quinine, which was also injected into living guinea pigs. When a physiological response was registered, the cells and cochleae were fixed and examined by transmission electron microscopy. In the isolated cells the formation of a central microtubule core occurred and in the cochleae a swelling of the subsurface cisternae in the outer hair cells was observed. The results are discussed in the context of a proposed effect of quinine on the contractile processes of the outer hair cells.
已证实外毛细胞具有运动特性，这可能参与了耳蜗的功能。已知奎宁可导致听力损失以及骨骼肌收缩。从豚鼠分离出的外毛细胞和分离出的耳蜗已暴露于奎宁，奎宁也被注射到活体豚鼠体内。当记录到生理反应时，将细胞和耳蜗固定，并用透射电子显微镜检查。在分离的细胞中观察到中央微管核心的形成，在耳蜗中观察到外毛细胞表面下池的肿胀。结合奎宁对外毛细胞收缩过程的推测作用对结果进行了讨论。
