Nakai Y, Konishi K, Chang K C, Ohashi K, Morisaki N, Minowa Y, Morimoto A
Acta Otolaryngol. 1982;93(1-6):227-32. doi: 10.3109/00016488209130876.
Cisplatin was administered to guinea pigs. Hearing function was tested using ABR, and morphological studies were conducted by scanning and transmission electron microscopy. The following findings were made. (1) The susceptibility to cochlear damage by cisplatin was dose dependent. (2) At the same dose, damage was most severe in the lower turns, particularly in the second turn. This tallies with the high tone loss. (3) Mainly the outer hair cells are the site of the damage and the inner hair cells are rarely damaged. (4) The first row of the outer hair cells tend to be more severely damaged. (5) Variation of the stria vascularis was moderate compared with the damage to the organ of Corti. (6) A tendency of recovery was observed in ABR in some animals after they were given 2 mg/kg/day cisplatin intramuscularly consecutively for 8 days.
对豚鼠施用顺铂。使用听性脑干反应（ABR）测试听力功能，并通过扫描电子显微镜和透射电子显微镜进行形态学研究。得出以下结果：（1）顺铂对耳蜗损伤的易感性呈剂量依赖性。（2）在相同剂量下，损伤在耳蜗下转最为严重，尤其是第二转。这与高音调听力损失相符。（3）主要是外毛细胞是损伤部位，内毛细胞很少受损。（4）外毛细胞的第一排往往受损更严重。（5）与柯蒂氏器的损伤相比，血管纹的变化程度适中。（6）在一些动物连续8天每天肌肉注射2mg/kg顺铂后，观察到其ABR有恢复的趋势。
