Li S H, Fei X, Gong X Q, Wu Z L
Department of Pathophysiology, Second Military Medical University, Shanghai.
Yao Xue Xue Bao. 1991;26(1):6-9.
Intravenous injection of E. coli endotoxin 30 mg/kg to rats resulted in a systemic hypotension and rapid decrease in mesenteric arteriolar blood flow velocity (MABFV). The mesenteric arterioles constricted within 3 min followed by a short period of vasodilation after endotoxin administration. Pretreatment with the platelet-activating factor receptor antagonist SRI 63-441 attenuated the endotoxin-induced systemic hypotension and the decrease in MABFV, and abolished the mesenteric vasodilation effect of endotoxin infusion. The results suggest that PAF may be a mediator of endotoxic shock.
给大鼠静脉注射30毫克/千克大肠杆菌内毒素，导致全身低血压和肠系膜小动脉血流速度（MABFV）迅速下降。内毒素给药后3分钟内肠系膜小动脉收缩，随后有一段短暂的血管舒张期。用血小板活化因子受体拮抗剂SRI 63 - 441预处理可减轻内毒素诱导的全身低血压和MABFV的下降，并消除内毒素输注的肠系膜血管舒张作用。结果表明，血小板活化因子（PAF）可能是内毒素休克的介质。
