来自人肝脏的AA型淀粉样原纤维提取物中的高分子量糖胺聚糖
High molecular weight glycosaminoglycans in AA type amyloid fibril extracts from human liver.
作者信息
Magnus J H, Kolset S O, Husby G
机构信息
Institute of Medical Biology, University of Tromsø, Norway.
出版信息
Ann Rheum Dis. 1991 Aug;50(8):562-6. doi: 10.1136/ard.50.8.562.
Abstract
Glycosaminoglycans have previously been identified in extracts of AA type hepatic amyloid fibril from a patient with amyloidosis associated with juvenile rheumatoid arthritis. The macromolecular properties of these polysaccharides are described here in more detail. By gel filtration and ion exchange chromatography glycosaminoglycans in the form of high molecular weight free chains were shown to coisolate with water extracted amyloid fibrils. About 60% of these were characterised as galactosamines (chondroitin sulphate/dermatan sulphate), whereas the remaining 40% consisted of N-sulphated glucosamines (heparin/heparan sulphate). The amyloid associated glycosaminoglycans were not part of intact proteoglycans in the fibril extracts.
摘要
先前已在一名患有青少年类风湿性关节炎相关淀粉样变性病患者的AA型肝淀粉样原纤维提取物中鉴定出糖胺聚糖。本文更详细地描述了这些多糖的大分子特性。通过凝胶过滤和离子交换色谱法，显示出高分子量游离链形式的糖胺聚糖与水提取的淀粉样原纤维共分离。其中约60%被鉴定为半乳糖胺（硫酸软骨素/硫酸皮肤素），而其余40%由N-硫酸化葡糖胺（肝素/硫酸乙酰肝素）组成。淀粉样相关糖胺聚糖不是纤维提取物中完整蛋白聚糖的一部分。
相似文献
1
High molecular weight glycosaminoglycans in AA type amyloid fibril extracts from human liver.来自人肝脏的AA型淀粉样原纤维提取物中的高分子量糖胺聚糖
Ann Rheum Dis. 1991 Aug;50(8):562-6. doi: 10.1136/ard.50.8.562.
2
Macromolecular properties of glycosaminoglycans in primary AL amyloid fibril extracts of lymphoid tissue origin.淋巴组织来源的原发性AL淀粉样原纤维提取物中糖胺聚糖的大分子特性。
Scand J Immunol. 1991 Nov;34(5):611-7. doi: 10.1111/j.1365-3083.1991.tb01584.x.
3
Presence of glycosaminoglycans in purified AA type amyloid fibrils associated with juvenile rheumatoid arthritis.与青少年类风湿性关节炎相关的纯化AA型淀粉样原纤维中存在糖胺聚糖。
Ann Rheum Dis. 1989 Mar;48(3):215-9. doi: 10.1136/ard.48.3.215.
4
Glycosaminoglycans in extracts of cardiac amyloid fibrils from familial amyloid cardiomyopathy of Danish origin related to variant transthyretin Met 111.来自丹麦起源的与变异甲状腺素运载蛋白Met 111相关的家族性淀粉样心肌病心脏淀粉样原纤维提取物中的糖胺聚糖。
Scand J Immunol. 1991 Jul;34(1):63-9. doi: 10.1111/j.1365-3083.1991.tb01521.x.
5
Identification of glycosaminoglycans in human renal and splenic secondary AA amyloid fibril preparations.人肾和脾继发性AA淀粉样原纤维制剂中糖胺聚糖的鉴定
Scand J Rheumatol. 1991;20(1):1-7. doi: 10.3109/03009749109165915.
6
Characterization of proteoglycans associated with mouse splenic AA amyloidosis.与小鼠脾脏AA型淀粉样变性相关的蛋白聚糖的特性分析
Biochem J. 1994 Oct 15;303 ( Pt 2)(Pt 2):663-70. doi: 10.1042/bj3030663.
7
On the association between amyloid fibrils and glycosaminoglycans; possible interactive role of Ca2+ and amyloid P-component.关于淀粉样纤维与糖胺聚糖之间的关联；钙离子和淀粉样P成分可能的相互作用角色。
Clin Exp Immunol. 1993 Oct;94(1):189-95. doi: 10.1111/j.1365-2249.1993.tb05999.x.
8
Analysis of glycosaminoglycan chains from different proteoglycan populations in human embryonic skin fibroblasts.人胚胎皮肤成纤维细胞中不同蛋白聚糖群体的糖胺聚糖链分析
Eur J Biochem. 1992 Sep 1;208(2):537-46. doi: 10.1111/j.1432-1033.1992.tb17218.x.
9
Isolation and partial characterization of heparan sulphate proteoglycans from human hepatic amyloid.从人肝脏淀粉样蛋白中分离和部分鉴定硫酸乙酰肝素蛋白聚糖
Biochem J. 1992 Nov 15;288 ( Pt 1)(Pt 1):225-31. doi: 10.1042/bj2880225.
10
A close ultrastructural relationship between sulfated proteoglycans and AA amyloid fibrils.硫酸化蛋白聚糖与AA淀粉样纤维之间紧密的超微结构关系。
Lab Invest. 1987 Dec;57(6):687-98.
引用本文的文献
1
On the association between amyloid fibrils and glycosaminoglycans; possible interactive role of Ca2+ and amyloid P-component.关于淀粉样纤维与糖胺聚糖之间的关联；钙离子和淀粉样P成分可能的相互作用角色。
Clin Exp Immunol. 1993 Oct;94(1):189-95. doi: 10.1111/j.1365-2249.1993.tb05999.x.
2
Isolation and partial characterization of heparan sulphate proteoglycans from human hepatic amyloid.从人肝脏淀粉样蛋白中分离和部分鉴定硫酸乙酰肝素蛋白聚糖
Biochem J. 1992 Nov 15;288 ( Pt 1)(Pt 1):225-31. doi: 10.1042/bj2880225.
本文引用的文献
1
A modified uronic acid carbazole reaction.一种改良的糖醛酸咔唑反应。
Anal Biochem. 1962 Oct;4:330-4. doi: 10.1016/0003-2697(62)90095-7.
2
The major proteins of human and monkey amyloid substance: Common properties including unusual N-terminal amino acid sequences.人类和猴子淀粉样物质的主要蛋白质：共同特性，包括不寻常的N端氨基酸序列。
FEBS Lett. 1971 Dec 1;19(2):169-173. doi: 10.1016/0014-5793(71)80506-9.
3
Comparative studies of the high molecular weight amyloid fibril proteins and similar components from normal tissues.正常组织中高分子量淀粉样原纤维蛋白及类似成分的比较研究。
Clin Exp Immunol. 1983 Jun;52(3):693-701.
4
The association of amyloid P-component (AP) with the amyloid fibril: an updated method for amyloid fibril protein isolation.淀粉样蛋白P成分（AP）与淀粉样纤维的关联：一种用于淀粉样纤维蛋白分离的更新方法。
Prep Biochem. 1982;12(5):461-76. doi: 10.1080/10826068208070597.
5
Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).淀粉样沉积物与淀粉样变性。β-纤维蛋白原（两部分中的第一部分）。
N Engl J Med. 1980 Jun 5;302(23):1283-92. doi: 10.1056/NEJM198006053022305.
6
The characterization of soluble amyloid prepared in water.在水中制备的可溶性淀粉样蛋白的特性
J Clin Invest. 1968 Apr;47(4):924-33. doi: 10.1172/JCI105784.
7
Human amyloid protein: chemical variability and homogeneity.人淀粉样蛋白：化学变异性与同质性。
J Histochem Cytochem. 1971 Jan;19(1):1-15. doi: 10.1177/19.1.1.
8
A method for the determination of the molecular weight and molecular-weight distribution of chondroitin sulphate.一种测定硫酸软骨素分子量及分子量分布的方法。
J Chromatogr. 1971 Jul 8;59(1):87-97. doi: 10.1016/s0021-9673(01)80009-1.
9
Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates.用于测定少量异构硫酸软骨素的酶法。
J Biol Chem. 1968 Apr 10;243(7):1536-42.
10
Mucopolysaccharides of whole human spleens in generalized amyloidosis.全身性淀粉样变性中全人类脾脏的黏多糖
J Clin Invest. 1966 Jun;45(6):963-75. doi: 10.1172/JCI105412.
Zotero 插件