García-Rodríguez J A, García Sánchez J E, García García M I, García Sánchez E, Muñoz Bellido J L
Department of Microbiology, Hospital Clínico Universitario, Salamanca, Spain.
Diagn Microbiol Infect Dis. 1991 May-Jun;14(3):239-43. doi: 10.1016/0732-8893(91)90038-h.
The susceptibility of 42 strains of Xanthomonas (Pseudomonas) maltophilia to 37 antibiotics (mainly beta-lactams, aminoglycosides, and fluorinated quinolones) was tested. Xanthomonas maltophilia was resistant to most beta-lactams, with ceftazidime, moxalactam, and ICI-194008 being the most active ones. Aminoglycosides had a very modest activity, with quinolones showing only moderate activity against this species. Trimethoprim/sufamethoxazole was effective against all strains tested. We also tested the synergy of several beta-lactam/beta-lactamase inhibitors against X. maltophilia. Only aztreonam/clavulanic acid at 3:1, 1:1 and, mainly, 2:1 combinations had synergistic activity, decreasing the rate of resistance from 92.8% for aztreonam alone to 32.4% for aztreonam-clavulanic acid at 1:1 and 0% for aztreonam-clavulanic acid at 2:1.
检测了42株嗜麦芽窄食单胞菌（假单胞菌属）对37种抗生素（主要是β-内酰胺类、氨基糖苷类和氟喹诺酮类）的敏感性。嗜麦芽窄食单胞菌对大多数β-内酰胺类耐药，头孢他啶、莫西沙星和ICI-194008是活性最强的。氨基糖苷类活性很弱，喹诺酮类对该菌仅表现出中等活性。甲氧苄啶/磺胺甲恶唑对所有测试菌株均有效。我们还测试了几种β-内酰胺类/β-内酰胺酶抑制剂对嗜麦芽窄食单胞菌的协同作用。只有氨曲南/克拉维酸在3:1、1:1以及主要是2:1的组合具有协同活性，将单独使用氨曲南时92.8%的耐药率降至氨曲南-克拉维酸1:1组合时的32.4%以及氨曲南-克拉维酸2:1组合时的0%。
