Kondo S, Abe K
Children's Asthmatic Center, Kawasaki City Ida Hospital, Japan.
Chest. 1991 Sep;100(3):640-3. doi: 10.1378/chest.100.3.640.
To study the temporal relation between the peak of circadian variation of bronchial responsiveness and the trough of circadian variation of bronchial caliber, we performed seven inhalation challenges with histamine at 4-h intervals in six stable asthmatic children aged eight to ten years. Bronchial responsiveness was expressed as PC20. Coefficient of variation of baseline FEV1 within the study day was less than 7 percent in all. The trough of FEV1 variation by cosinor analysis ranged from 02.50 to 11.99 h (mean, 05.66). All had both significant (p less than 0.05) or marginally significant (0.05 less than p less than 0.1) cosinusoidal rhythm of PC20 and two or more doubling concentration differences between the highest and lowest PC20s. The trough of PC20 variation ranged from 16.32 to 02.87 h (mean, 22.30). There was a significant (p less than 0.05) difference between troughs of FEV1 and PC20 variations. We conclude that the peak of circadian variation of bronchial responsiveness precedes the trough of circadian variation of bronchial caliber in asthmatic children.
为研究支气管反应性昼夜变化峰值与支气管管径昼夜变化谷值之间的时间关系，我们对6名8至10岁病情稳定的哮喘儿童每隔4小时进行一次组胺吸入激发试验，共进行了7次。支气管反应性以PC20表示。在研究日期间，所有儿童的基线第一秒用力呼气容积（FEV1）变异系数均小于7%。通过余弦分析得出的FEV1变异谷值范围为02:50至11:99时（平均为05:66）。所有儿童的PC20均有显著（p<0.05）或边缘显著（0.05<p<0.1）的余弦节律，且最高和最低PC20之间有两个或更多倍浓度差异。PC20变异谷值范围为16:32至02:87时（平均为22:30）。FEV1和PC20变异谷值之间存在显著（p<0.05）差异。我们得出结论，哮喘儿童中支气管反应性的昼夜变化峰值先于支气管管径的昼夜变化谷值。
