Stoorvogel J, van Gestel M H, Ketelaar-van Gaalen P A, Mouton R P, van de Klundert J A
Department of Medical Microbiology, University Hospital, Leiden, The Netherlands.
Chemotherapy. 1991;37(3):175-85. doi: 10.1159/000238851.
Eight strains of Enterobacter cloacae with varying patterns of susceptibility to beta-lactam antibiotics were studied to compare the inducibility and expression of their beta-lactamase genes. These strains included two isolates from one patient, which differed in their susceptibility to cefamandole. A resistant strain constitutively produced large amounts of beta-lactamase; a sensitive strain produced an inducible beta-lactamase. Study of induction and growth characteristics of all strains revealed that the induction and the expression of inducible beta-lactamase genes may vary considerably among strains of E. cloacae.
对八株对β-内酰胺类抗生素敏感性模式各异的阴沟肠杆菌进行了研究，以比较其β-内酰胺酶基因的诱导性和表达情况。这些菌株包括来自一名患者的两株分离菌，它们对头孢孟多的敏感性不同。一株耐药菌株组成性地产生大量β-内酰胺酶；一株敏感菌株产生可诱导的β-内酰胺酶。对所有菌株的诱导和生长特性研究表明，阴沟肠杆菌菌株中可诱导β-内酰胺酶基因的诱导和表达可能有很大差异。
