早期胚胎聚集法制备小鼠嵌合体的应用。II. 疾病过程的研究。

The use of early embryo aggregation derived mouse chimaeras. II. The study of disease processes.

作者信息

Barnes R D

出版信息

J Immunogenet. 1976 Dec;3(6):411-21. doi: 10.1111/j.1744-313x.1976.tb00603.x.

DOI:10.1111/j.1744-313x.1976.tb00603.x

Abstract

Early embryo aggregation derived mouse chimeras have proven an extremely valuable tool to study development of disease processes. In this respect chimaeras prove a unique opportunity to study the interaction between cells genetically pre-destined to become diseased and a normal cell population within the same animal. In this situation chimaeras can be studied in view of possible 'correction' of the disease by the provision of a population of normal host cells and/or their products. Various host deficiency states including classic immune deficiency, potentially 'deficient' anemias and tumours have been studied--the subject of the review here.

摘要

早期胚胎聚集衍生的小鼠嵌合体已被证明是研究疾病过程发展的极其有价值的工具。在这方面，嵌合体为研究注定会患病的基因细胞与同一动物体内正常细胞群之间的相互作用提供了独特的机会。在这种情况下，可以考虑通过提供正常宿主细胞群和/或其产物来“纠正”疾病，从而对嵌合体进行研究。包括经典免疫缺陷、潜在“缺陷”性贫血和肿瘤在内的各种宿主缺陷状态都已得到研究——这也是本文综述的主题。