Arend O, Wolf S, Schulte K, Jung F, Bertram B, Reim M
Augenklinik, Medizinischen Fakultät der RWTH, Aachen, Bundesrepublik Deutschland.
Fortschr Ophthalmol. 1991;88(3):243-7.
Forty-two patients with branch vein or central retinal vein occlusion were enrolled in this randomized placebo-controlled study. We studied the influence of hemodilution therapy with hydroxyethyl-starch (HAES-steril) combined with pentoxifylline (Trental) for 6 months. In the bulbar conjunctiva, capillary red blood cell (RBC) velocities and vessel diameters and rheological parameters of hematocrit, erythrocyte aggregation and plasma viscosity were examined. In the hemodilution group we observed no changes in vessel diameter and a significant increase in RBC velocity after therapy. After 6 weeks the RBC velocity showed 30% higher values but there was no statistically significant difference. After hemodilution therapy hematocrit, erythrocyte aggregation and plasma viscosity were significantly different from those in the control group. After 6 weeks we observed significant differences only in erythrocyte aggregation. This examination verifies the positive influence of hemodilution therapy on microcirculation and hemorheology.
42例视网膜分支静脉或视网膜中央静脉阻塞患者被纳入这项随机安慰剂对照研究。我们研究了羟乙基淀粉（HAES-steril）联合己酮可可碱（曲克芦丁）进行6个月血液稀释疗法的影响。检测球结膜毛细血管红细胞（RBC）速度、血管直径以及血细胞比容、红细胞聚集和血浆黏度等流变学参数。在血液稀释组，我们观察到治疗后血管直径无变化，红细胞速度显著增加。6周后，红细胞速度显示出高30%的值，但无统计学显著差异。血液稀释治疗后，血细胞比容、红细胞聚集和血浆黏度与对照组有显著差异。6周后，我们仅观察到红细胞聚集有显著差异。这项检查证实了血液稀释疗法对微循环和血液流变学的积极影响。
