Livshits G, Kobyliansky E
Department of Anatomy and Anthropology, Sackler, Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Hum Biol. 1991 Aug;63(4):441-66.
We investigate three hypotheses related to fluctuating asymmetry (FA) of bilateral morphologic traits in humans: (1) the magnitude of FA in individual suffering from different levels of morbidity is significantly elevated compared with FA in healthy control subjects, (2) FA is negatively correlated with an individual's heterozygosity, and (3) phenotypic variance of FA may have a significant genetic component (or at least a family resemblance). Our experimental data and the literature support the first hypothesis and indicate that individuals who suffer from chromosomal or polygenic morbidity and from anomalies or conditions of development with still unknown genetic components demonstrate an elevated FA of various structures. The literature regarding the second hypothesis is sparse but is generally in agreement with it, although some exceptions exist. A study of correlations of phenotypic scores of FA between family members of nuclear families in two independent samples has shown that FA variance in individual traits probably does not have any significant genetic component. However, phenotypic variance of the mean estimate of FA over 8 traits showed significant additive and nonadditive (dominance) genetic components, each about 0.30.
我们研究了与人类双侧形态特征波动不对称性（FA）相关的三个假说：（1）与健康对照受试者相比，患有不同发病程度的个体的FA程度显著升高；（2）FA与个体的杂合性呈负相关；（3）FA的表型变异可能具有显著的遗传成分（或至少存在家族相似性）。我们的实验数据和文献支持第一个假说，并表明患有染色体或多基因疾病以及患有遗传成分仍未知的发育异常或病症的个体表现出各种结构的FA升高。关于第二个假说的文献较少，但总体上与之相符，不过也存在一些例外情况。对两个独立样本中核心家庭家庭成员之间FA表型评分的相关性研究表明，个体性状的FA变异可能没有任何显著的遗传成分。然而，8个性状的FA平均估计值的表型变异显示出显著的加性和非加性（显性）遗传成分，每个约为0.30。
