Gou K J, Fujii S, Konishi I, Nanbu Y, Nonogaki H, Iwai T, Ishikawa Y, Wang D P, Mori T
Department of Gynecology, No. 1 Hospital of China Medical University.
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Jul;43(7):749-55.
Eight patients with cervical carcinoma with massive stromal infiltration of eosinophils were selected for a clinicopathological study among 474 patients with cervical carcinoma at stages Ib-IIIb who underwent radical hysterectomy between 1971 and 1989 at Kyoto University Hospital. The 8 patients ranged in age from 28 to 48 years and had menstrual cycles. The peripheral leucocyte count in 5 patients showed eosinophilia of the peripheral blood. Histologically, the cervical carcinoma was a locally advanced tumor with invasion of more than 2/3rds the depth of the cervical wall in 6 cases, and with parametrial involvement in 4 cases. Massive infiltration of eosinophils was observed not only around the cancer nests but also within the regional lymph nodes. Mast cells expressing immunoreactivity for histamine were scarce around the tumor. Consequently, the production of an eosinophil chemotactic factor by the tumor cells was strongly suggested. PAS and Alcian-blue staining as well as electron microscopy revealed that the tumor cells in most cases had the histological characteristics of both squamous carcinoma and adenocarcinoma. Collectively, these clinicopathological characteristics of cervical carcinoma with massive infiltration of eosinophils distinguish this tumor from conventional cervical carcinomas.
在1971年至1989年间于京都大学医院接受根治性子宫切除术的474例Ib-IIIb期宫颈癌患者中，选取了8例伴有大量嗜酸性粒细胞间质浸润的宫颈癌患者进行临床病理研究。这8例患者年龄在28至48岁之间，均有月经周期。5例患者的外周血白细胞计数显示外周血嗜酸性粒细胞增多。组织学上，宫颈癌为局部晚期肿瘤，6例侵犯宫颈壁深度超过2/3，4例伴有宫旁组织受累。不仅在癌巢周围，而且在区域淋巴结内均观察到大量嗜酸性粒细胞浸润。肿瘤周围表达组胺免疫反应性的肥大细胞稀少。因此，强烈提示肿瘤细胞产生了嗜酸性粒细胞趋化因子。PAS和阿尔辛蓝染色以及电子显微镜检查显示，大多数病例中的肿瘤细胞具有鳞状细胞癌和腺癌的组织学特征。总体而言，伴有大量嗜酸性粒细胞浸润的宫颈癌的这些临床病理特征使其有别于传统宫颈癌。
