Tamate K, Sengoku K, Ishikawa M, Shimizu T, Haga H, Hasegawa T, Takada H, Mure K, Kawamura M, Torii Y
Department of Obstetrics and Gynecology, Asahikawa Medical College.
Jpn J Antibiot. 1991 Jun;44(6):643-51.
The placental passage and the the therapeutic efficacy of flomoxef (FMOX, 6315-S) were studied in patients in the perinatal period. A summary of the obtained results is as follows: 1. Concentrations of FMOX in maternal serum, umbilical cord serum and amniotic fluid obtained upon one-shot intravenous injections to 12 patients were compared with those obtained upon 1 hour drip infusions to 9 patients. It was found that the former means of administration gave higher concentrations that the latter. 2. Concentrations of FMOX in maternal serum, umbilical cord serum and amniotic fluid at 1 to 6 hours after administration through either method were all higher than MIC80's of recognized bacteria. 3. Clinical efficacies were evaluated in 10 patients with puerperal intrauterine infection, 7 patients with endometritis, 2 patients with pyelonephritis and 1 patient each with endo-cervicitis, amniotic fluid infection, mastitis and perineal wound infection. Clinical efficacies were excellent in 5 patients (21.7%), good in 17 patients (73.9%) and poor in 1 patient (4.4%), thus the overall efficacy rate was 95.7%. 4. Eradication of causative bacteria were obtained in all 8 cases tested, hence the eradication rate was 100%. 5. Mild diarrhea in 1 patient was the only side effect observed. No abnormal clinical laboratory test results were found in any patients.
对围产期患者的氟氧头孢（FMOX，6315-S）胎盘转运及治疗效果进行了研究。所得结果总结如下：1. 将12例患者单次静脉注射后获得的母体血清、脐带血清和羊水中FMOX的浓度与9例患者1小时滴注后获得的浓度进行比较。发现前一种给药方式产生的浓度高于后一种。2. 通过任何一种方法给药后1至6小时，母体血清、脐带血清和羊水中FMOX的浓度均高于公认细菌的MIC80。3. 对10例产褥期子宫内感染患者、7例子宫内膜炎患者、2例肾盂肾炎患者以及各1例宫颈炎、羊水感染、乳腺炎和会阴伤口感染患者的临床疗效进行了评估。临床疗效优5例（21.7%），良17例（73.9%），差1例（4.4%），总有效率为95.7%。4. 在所检测的8例病例中均实现了病原菌的清除，清除率为100%。5. 仅观察到1例患者出现轻度腹泻。未发现任何患者的临床实验室检查结果异常。
